Long noncoding RNA EMS connects c-Myc to cell cycle control and tumorigenesis.

Wang, Chenfeng; Yang, Yang; Zhang, Guang; Li, Jingxin; Wu, Xianning; Ma, Xiaoling; Shan, Ge; Mei, Yide

Wang, Chenfeng; Yang, Yang; Zhang, Guang; Li, Jingxin; Wu, Xianning; Ma, Xiaoling; Shan, Ge; Mei, Yide.

Afiliação

Wang C; Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, First Affiliated Hospital of University of Science and Technology of China, School of Life Sciences, University of Science and Technology of China (USTC), 230027 Hefei, Anhui, China.
Yang Y; Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, USTC, 230027 Hefei, Anhui, China.
Zhang G; Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, First Affiliated Hospital of University of Science and Technology of China, School of Life Sciences, University of Science and Technology of China (USTC), 230027 Hefei, Anhui, China.
Li J; Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, USTC, 230027 Hefei, Anhui, China.
Wu X; Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, First Affiliated Hospital of University of Science and Technology of China, School of Life Sciences, University of Science and Technology of China (USTC), 230027 Hefei, Anhui, China.
Ma X; Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, USTC, 230027 Hefei, Anhui, China.
Shan G; Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, First Affiliated Hospital of University of Science and Technology of China, School of Life Sciences, University of Science and Technology of China (USTC), 230027 Hefei, Anhui, China.
Mei Y; Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, USTC, 230027 Hefei, Anhui, China.

Proc Natl Acad Sci U S A ; 116(29): 14620-14629, 2019 07 16.

Article em En | MEDLINE | ID: mdl-31262817

Assuntos

Carcinogênese/genética; Pontos de Checagem da Fase G1 do Ciclo Celular/genética; Neoplasias/genética; Proteínas Proto-Oncogênicas c-myc/metabolismo; RNA Longo não Codificante/genética; Células A549; Animais; Fator de Transcrição E2F1/genética; Regulação Neoplásica da Expressão Gênica; Técnicas de Silenciamento de Genes; Células HEK293; Ribonucleoproteínas Nucleares Heterogêneas Grupo C/metabolismo; Humanos; Camundongos; Neoplasias/patologia; Proteínas Proto-Oncogênicas c-myc/genética; Estabilidade de RNA/genética; RNA Longo não Codificante/metabolismo; RNA Mensageiro/metabolismo; RNA Interferente Pequeno/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

E2F1; c-Myc; lncRNA; tumorigenesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-myc / Pontos de Checagem da Fase G1 do Ciclo Celular / RNA Longo não Codificante / Carcinogênese / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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