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Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.
Haile, Pamela A; Casillas, Linda N; Votta, Bartholomew J; Wang, Gren Z; Charnley, Adam K; Dong, Xiaoyang; Bury, Michael J; Romano, Joseph J; Mehlmann, John F; King, Bryan W; Erhard, Karl F; Hanning, Charles R; Lipshutz, David B; Desai, Biva M; Capriotti, Carol A; Schaeffer, Michelle C; Berger, Scott B; Mahajan, Mukesh K; Reilly, Michael A; Nagilla, Rakesh; Rivera, Elizabeth J; Sun, Helen H; Kenna, John K; Beal, Allison M; Ouellette, Michael T; Kelly, Mike; Stemp, Gillian; Convery, Máire A; Vossenkämper, Anna; MacDonald, Thomas T; Gough, Peter J; Bertin, John; Marquis, Robert W.
Afiliação
  • Haile PA; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Casillas LN; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Votta BJ; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Wang GZ; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Charnley AK; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Dong X; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Bury MJ; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Romano JJ; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Mehlmann JF; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • King BW; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Erhard KF; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Hanning CR; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Lipshutz DB; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Desai BM; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Capriotti CA; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Schaeffer MC; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Berger SB; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Mahajan MK; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Reilly MA; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Nagilla R; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Rivera EJ; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Sun HH; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Kenna JK; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Beal AM; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Ouellette MT; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Kelly M; GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Stemp G; GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Convery MA; GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Vossenkämper A; Centre for Immunobiology, Blizard Institute, Barts and The London School of Medicine and Dentistry , Queen Mary University of London , London E1 2AD , U.K.
  • MacDonald TT; Centre for Immunobiology, Blizard Institute, Barts and The London School of Medicine and Dentistry , Queen Mary University of London , London E1 2AD , U.K.
  • Gough PJ; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Bertin J; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Marquis RW; GlaxoSmithKline , Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
J Med Chem ; 62(14): 6482-6494, 2019 07 25.
Article em En | MEDLINE | ID: mdl-31265286
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfatos / Quinazolinas / Inibidores de Proteínas Quinases / Benzotiazóis / Proteína Serina-Treonina Quinase 2 de Interação com Receptor Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfatos / Quinazolinas / Inibidores de Proteínas Quinases / Benzotiazóis / Proteína Serina-Treonina Quinase 2 de Interação com Receptor Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos