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A nano-sized gel-in-oil suspension for transcutaneous protein delivery.
Hardiningtyas, Safrina Dyah; Nagao, Seiya; Yamamoto, Emiko; Shirakigawa, Nana; Wakabayashi, Rie; Goto, Masahiro; Ijima, Hiroyuki; Kamiya, Noriho.
Afiliação
  • Hardiningtyas SD; Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-0395, Japan. Electronic address: safrina_dyah@apps.ipb.ac.id.
  • Nagao S; Department of Chemical Engineering, Graduate School of Engineering, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-0395, Japan. Electronic address: s_nagao@kyudai.jp.
  • Yamamoto E; Department of Chemical Engineering, Graduate School of Engineering, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-0395, Japan. Electronic address: yamaemi@kyudai.jp.
  • Shirakigawa N; Department of Chemical Engineering, Graduate School of Engineering, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-0395, Japan. Electronic address: shirakigawa@chem-eng.kyushu-u.ac.jp.
  • Wakabayashi R; Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-0395, Japan. Electronic address: rie_wakaba@mail.cstm.kyushu-u.ac.jp.
  • Goto M; Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-0395, Japan; Division of Biotechnology, Center for Future Chemistry, Kyushu University, Japan. Electronic address: m-goto@mail.cstm.kyushu-u.ac.jp.
  • Ijima H; Department of Chemical Engineering, Graduate School of Engineering, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-0395, Japan. Electronic address: ijima@chem-eng.kyushu-u.ac.jp.
  • Kamiya N; Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-0395, Japan; Division of Biotechnology, Center for Future Chemistry, Kyushu University, Japan. Electronic address: kamiya.noriho.367@m.kyushu-u.ac.jp.
Int J Pharm ; 567: 118495, 2019 Aug 15.
Article em En | MEDLINE | ID: mdl-31276761
ABSTRACT
We developed a new oil-based delivery system for transdermal protein delivery, a gel-in-oil (G/O) nanosuspension, where gelatin-based hydrogel was coated with hydrophobic surfactants. The high entrapment efficiency of a model protein, phycocyanin (PC), into nano-sized gelatin hydrogel particles was achieved. Spectroscopic evaluation of PC suggested that the G/O nanosuspension could retain the functional form of PC in isopropyl myristate. In vitro skin permeation studies showed that the G/O nanosuspension facilitated the delivery of PC through the stratum corneum of Yucatan micropig skin.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ficocianina / Portadores de Fármacos / Hidrogéis / Nanopartículas / Gelatina / Miristatos Limite: Animals Idioma: En Revista: Int J Pharm Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ficocianina / Portadores de Fármacos / Hidrogéis / Nanopartículas / Gelatina / Miristatos Limite: Animals Idioma: En Revista: Int J Pharm Ano de publicação: 2019 Tipo de documento: Article