A nano-sized gel-in-oil suspension for transcutaneous protein delivery.
Int J Pharm
; 567: 118495, 2019 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-31276761
ABSTRACT
We developed a new oil-based delivery system for transdermal protein delivery, a gel-in-oil (G/O) nanosuspension, where gelatin-based hydrogel was coated with hydrophobic surfactants. The high entrapment efficiency of a model protein, phycocyanin (PC), into nano-sized gelatin hydrogel particles was achieved. Spectroscopic evaluation of PC suggested that the G/O nanosuspension could retain the functional form of PC in isopropyl myristate. In vitro skin permeation studies showed that the G/O nanosuspension facilitated the delivery of PC through the stratum corneum of Yucatan micropig skin.
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Base de dados:
MEDLINE
Assunto principal:
Ficocianina
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Portadores de Fármacos
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Hidrogéis
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Nanopartículas
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Gelatina
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Miristatos
Limite:
Animals
Idioma:
En
Revista:
Int J Pharm
Ano de publicação:
2019
Tipo de documento:
Article