Role of complement in patients with autoimmune hemolytic anemia and platelet transfusion refractoriness.
Transfus Clin Biol
; 26(3): 152-154, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-31277985
ABSTRACT
The complement is a key player of the innate immune response. It provides defense mechanisms that are not specific, but very efficient at neutralizing any invader, accounting for 4% of the proteins in the peripheral blood. Nevertheless, there is a dark side to the complement system, as it may activate its machinery against healthy cells such as peripheral blood red blood cells and platelets resulting in undesired hemolysis and thrombocytopenia, respectively. Understanding and identifying the role of complement in these settings allow physicians to adjust their diagnostic and therapeutic modalities accordingly. The role of complement in the pathophysiology and management of autoimmune hemolytic anemia and of alloimmune-mediated thrombocytopenia is under investigation and discussed.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas do Sistema Complemento
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Transfusão de Plaquetas
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Imunidade Inata
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Anemia Hemolítica Autoimune
Limite:
Humans
Idioma:
En
Revista:
Transfus Clin Biol
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article