Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm titanium dioxide nanoparticle aerosols in healthy adult rats after a single two-hour inhalation exposure.

Kreyling, Wolfgang G; Holzwarth, Uwe; Schleh, Carsten; Hirn, Stephanie; Wenk, Alexander; Schäffler, Martin; Haberl, Nadine; Semmler-Behnke, Manuela; Gibson, Neil

Kreyling, Wolfgang G; Holzwarth, Uwe; Schleh, Carsten; Hirn, Stephanie; Wenk, Alexander; Schäffler, Martin; Haberl, Nadine; Semmler-Behnke, Manuela; Gibson, Neil.

Afiliação

Kreyling WG; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, D-85764, Munich, Neuherberg, Germany. kreyling@helmholtz-muenchen.de.
Holzwarth U; Institute of Epidemiology, Helmholtz Center Munich - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, D-85764, Munich, Neuherberg, Germany. kreyling@helmholtz-muenchen.de.
Schleh C; European Commission, Joint Research Centre (JRC), Ispra, Italy.
Hirn S; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, D-85764, Munich, Neuherberg, Germany.
Wenk A; Current address: Abteilung Gesundheit, Berufsgenossenschaft Holz und Metall, Am Knie 8, D-81241, München, Germany.
Schäffler M; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, D-85764, Munich, Neuherberg, Germany.
Haberl N; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, D-85764, Munich, Neuherberg, Germany.
Semmler-Behnke M; Current address: Dept. Infrastructure, Safety, Occupational Protection, Helmholtz Center München - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, D-85764, Munich, Neuherberg, Germany.
Gibson N; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, D-85764, Munich, Neuherberg, Germany.

Part Fibre Toxicol ; 16(1): 29, 2019 07 09.

Article em En | MEDLINE | ID: mdl-31288843

Assuntos

Exposição por Inalação/análise; Pulmão/metabolismo; Nanopartículas/química; Titânio/farmacocinética; Aerossóis; Animais; Líquido da Lavagem Broncoalveolar; Feminino; Taxa de Depuração Metabólica; Especificidade de Órgãos; Tamanho da Partícula; Ratos; Ratos Endogâmicos WKY; Mucosa Respiratória/metabolismo; Fatores de Tempo; Distribuição Tecidual; Titânio/química

Palavras-chave

Accumulation in secondary organs and tissues; Characterization of physicochemical particle properties; Intratracheal inhalation of freshly generated aerosols; Long-term alveolar macrophage-mediated nanoparticle clearance; Nanoparticle relocation into the interstitium; Re-entrainment from interstitium back to lung epithelium for clearance towards the larynx; Spark ignition generated titanium dioxide nanoparticle aerosols; Translocation across air-blood-barrier

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Titânio / Exposição por Inalação / Nanopartículas / Pulmão Limite: Animals Idioma: En Revista: Part Fibre Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha

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