PI3K/mTOR inhibition of IDH1 mutant glioma leads to reduced 2HG production that is associated with increased survival.

Batsios, Georgios; Viswanath, Pavithra; Subramani, Elavarasan; Najac, Chloe; Gillespie, Anne Marie; Santos, Romelyn Delos; Molloy, Abigail R; Pieper, Russell O; Ronen, Sabrina M

Batsios, Georgios; Viswanath, Pavithra; Subramani, Elavarasan; Najac, Chloe; Gillespie, Anne Marie; Santos, Romelyn Delos; Molloy, Abigail R; Pieper, Russell O; Ronen, Sabrina M.

Afiliação

Batsios G; Department of Radiology and Biomedical Imaging, Mission Bay Campus, 1700 4th Street, Byers Hall, University of California, 94158, San Francisco, CA, United States.
Viswanath P; Department of Radiology and Biomedical Imaging, Mission Bay Campus, 1700 4th Street, Byers Hall, University of California, 94158, San Francisco, CA, United States.
Subramani E; Department of Radiology and Biomedical Imaging, Mission Bay Campus, 1700 4th Street, Byers Hall, University of California, 94158, San Francisco, CA, United States.
Najac C; Department of Radiology and Biomedical Imaging, Mission Bay Campus, 1700 4th Street, Byers Hall, University of California, 94158, San Francisco, CA, United States.
Gillespie AM; Department of Radiology and Biomedical Imaging, Mission Bay Campus, 1700 4th Street, Byers Hall, University of California, 94158, San Francisco, CA, United States.
Santos RD; Department of Radiology and Biomedical Imaging, Mission Bay Campus, 1700 4th Street, Byers Hall, University of California, 94158, San Francisco, CA, United States.
Molloy AR; Department of Radiology and Biomedical Imaging, Mission Bay Campus, 1700 4th Street, Byers Hall, University of California, 94158, San Francisco, CA, United States.
Pieper RO; Department of Neurological Surgery, Helen Diller Research Center, 1450 3rd Street, University of California, 94143, San Francisco, CA, United States.
Ronen SM; Department of Radiology and Biomedical Imaging, Mission Bay Campus, 1700 4th Street, Byers Hall, University of California, 94158, San Francisco, CA, United States. sabrina.ronen@ucsf.edu.

Sci Rep ; 9(1): 10521, 2019 07 19.

Article em En | MEDLINE | ID: mdl-31324855

Assuntos

Neoplasias Encefálicas/metabolismo; Glioma/metabolismo; Glutaratos/metabolismo; Isocitrato Desidrogenase/genética; Proteínas de Neoplasias/genética; Fosfatidilinositol 3-Quinases/metabolismo; Serina-Treonina Quinases TOR/metabolismo; Proteínas Adaptadoras de Transdução de Sinal/antagonistas & inibidores; Animais; Astrócitos/metabolismo; Neoplasias Encefálicas/mortalidade; Proteínas de Ciclo Celular/antagonistas & inibidores; Linhagem Celular Transformada; Glioma/mortalidade; Glucose/metabolismo; Glutamina/metabolismo; Humanos; Estimativa de Kaplan-Meier; Camundongos; Proteínas de Neoplasias/metabolismo; Ressonância Magnética Nuclear Biomolecular; Fosforilação; Processamento de Proteína Pós-Traducional; Quinoxalinas/farmacologia; Quinoxalinas/uso terapêutico; Proteínas Quinases S6 Ribossômicas/metabolismo; Transdução de Sinais; Sulfonamidas/farmacologia; Sulfonamidas/uso terapêutico; Serina-Treonina Quinases TOR/antagonistas & inibidores; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Fosfatidilinositol 3-Quinases / Serina-Treonina Quinases TOR / Glioma / Glutaratos / Isocitrato Desidrogenase / Proteínas de Neoplasias Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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