Immunological and clinical effects of interferon-gamma on Crohn's disease.
J Clin Lab Immunol
; 25(3): 105-8, 1988 Mar.
Article
em En
| MEDLINE
| ID: mdl-3135410
ABSTRACT
Five patients with Crohn's disease (CD) confined to the small intestine were studied to determine whether intravenous administration of interferon (IFN)-gamma to normalize immunological imbalance produces clinical improvement. A daily dose of 12 million IU of IFN-gamma was intravenously infused for four weeks. Laboratory data, immunological responses, clinical and radiologic findings were evaluated after administration. Laboratory data showed no significant change after treatment. Immunological studies also failed to demonstrate any significant change except for a significant increase of natural killer (NK) cell activity after IFN-gamma infusion. Clinical assessment by Crohn's disease activity index as well as radiologic findings disclosed no definite improvement. This study suggests that enhancement of NK cell activity or augmentation of immunological imbalance induced by IFN-gamma does not play an important role in the pathogenesis of CD.
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Base de dados:
MEDLINE
Assunto principal:
Doença de Crohn
/
Interferon gama
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Lab Immunol
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Japão