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Exebacase in Addition to Daptomycin Is More Active than Daptomycin or Exebacase Alone in Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats.
Karau, Melissa J; Schmidt-Malan, Suzannah M; Yan, Qun; Greenwood-Quaintance, Kerryl E; Mandrekar, Jayawant; Lehoux, Dario; Schuch, Raymond; Cassino, Cara; Patel, Robin.
Afiliação
  • Karau MJ; Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
  • Schmidt-Malan SM; Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
  • Yan Q; Department of Clinical Laboratory, Xiangya Hospital of Central South University, Changsha, Hunan, China.
  • Greenwood-Quaintance KE; Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
  • Mandrekar J; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
  • Lehoux D; ContraFect, Yonkers, New York, USA.
  • Schuch R; ContraFect, Yonkers, New York, USA.
  • Cassino C; ContraFect, Yonkers, New York, USA.
  • Patel R; Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA patel.robin@mayo.edu.
Antimicrob Agents Chemother ; 63(10)2019 10.
Article em En | MEDLINE | ID: mdl-31358593
Bacteriophage-derived lysins are being developed as anti-infective agents. In an acute osteomyelitis methicillin-resistant Staphylococcus aureus (MRSA) model, rats receiving no treatment or treatment with daptomycin, exebacase (CF-301), or daptomycin plus exebacase had means of 5.13, 4.09, 4.65, and 3.57 log10 CFU/gram of bone, respectively. All treated animals had fewer bacteria than did untreated animals (P ≤ 0.0001), with daptomycin plus exebacase being more active than daptomycin (P = 0.0042) or exebacase (P < 0.001) alone.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteomielite / Endopeptidases / Daptomicina / Staphylococcus aureus Resistente à Meticilina / Antibacterianos Limite: Animals Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteomielite / Endopeptidases / Daptomicina / Staphylococcus aureus Resistente à Meticilina / Antibacterianos Limite: Animals Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos