Nerve-sparing versus non-nerve-sparing radical hysterectomy: surgical and long-term oncological outcomes.
Oncotarget
; 10(44): 4598-4608, 2019 Jul 16.
Article
em En
| MEDLINE
| ID: mdl-31360307
ABSTRACT
OBJECTIVES:
There are controversies regarding the long-term oncological safety of preservation of pelvic innervation during radical hysterectomy (RH). This study aimed to analyze the feasibility and safety of nerve-sparing radical hysterectomy (NSRH) for cervical cancer compared with non-NSRH following 17 years of experience in a tertiary cancer referral center. MATERIALS ANDMETHODS:
Between May 1999 and June 2016, all patients who underwent RH for cervical cancer were followed-up prospectively. Comparison analyses regarding surgical outcomes, complications, overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS) were performed between patients treated with NSRH and non-NSRH.RESULTS:
A total of 188 patients were included (113 non-NSRH and 75 NSRH). The median follow-up was 112 months. Estimated blood loss and hospital stay were all significantly lower in the NSRH group. Overall intraoperative complication rate (p = 0.02) and need for transfusion (p = 0.016) were lower in the NSRH group. There were no differences in the median operation time, OS, DFS, CSS, or recurrence rates between the NSRH and non-NSRH group.CONCLUSIONS:
Our study provides a wide perspective on the developments of nerve-sparing procedures for the management of women with early-stage cervical cancer. Our results suggest that NSRH is a feasible and safe procedure, with reduced morbidity outcomes.
Texto completo:
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Oncotarget
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Espanha