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Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice.
Tang, Xin; Drotar, Jesse; Li, Keji; Clairmont, Cullen D; Brumm, Anna Sophie; Sullins, Austin J; Wu, Hao; Liu, Xiaoxiao Shawn; Wang, Jinhua; Gray, Nathanael S; Sur, Mriganka; Jaenisch, Rudolf.
Afiliação
  • Tang X; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  • Drotar J; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  • Li K; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Clairmont CD; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  • Brumm AS; Francis Crick Institute, London NW1 1AT, UK .
  • Sullins AJ; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Wu H; Fulcrum Therapeutics, Cambridge, MA 02139, USA.
  • Liu XS; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  • Wang J; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
  • Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
  • Sur M; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Jaenisch R; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. jaenisch@wi.mit.edu.
Sci Transl Med ; 11(503)2019 07 31.
Article em En | MEDLINE | ID: mdl-31366578
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome de Rett / Simportadores / Proteína 2 de Ligação a Metil-CpG / Neurônios Limite: Animals / Female / Humans / Male Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome de Rett / Simportadores / Proteína 2 de Ligação a Metil-CpG / Neurônios Limite: Animals / Female / Humans / Male Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos