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Discovery of novel Schistosoma mansoni PDE4A inhibitors as potential agents against schistosomiasis.
Sebastián-Pérez, Víctor; Schroeder, Susanne; Munday, Jane C; van der Meer, Tiffany; Zaldívar-Díez, Josefa; Siderius, Marco; de Koning, Harry P; Brown, Dave; Martínez, Ana; Campillo, Nuria E; Leurs, Rob; Gil, Carmen.
Afiliação
  • Sebastián-Pérez V; Centro de Investigaciones Biológicas (CIB-CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain.
  • Schroeder S; School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK.
  • Munday JC; Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary & Life Sciences, University of Glasgow, 120 University Place, Glasgow, G12 8TA, UK.
  • van der Meer T; Department of Medicinal Chemistry, Amsterdam Institute of Molecules, Medicines & Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
  • Zaldívar-Díez J; Centro de Investigaciones Biológicas (CIB-CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain.
  • Siderius M; Department of Medicinal Chemistry, Amsterdam Institute of Molecules, Medicines & Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
  • de Koning HP; Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary & Life Sciences, University of Glasgow, 120 University Place, Glasgow, G12 8TA, UK.
  • Brown D; School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK.
  • Martínez A; Centro de Investigaciones Biológicas (CIB-CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain.
  • Campillo NE; Centro de Investigaciones Biológicas (CIB-CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain.
  • Leurs R; Department of Medicinal Chemistry, Amsterdam Institute of Molecules, Medicines & Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
  • Gil C; Centro de Investigaciones Biológicas (CIB-CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain.
Future Med Chem ; 11(14): 1703-1720, 2019 07.
Article em En | MEDLINE | ID: mdl-31370708
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Schistosoma mansoni / Esquistossomose / Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 / Descoberta de Drogas / Inibidores da Fosfodiesterase 4 Limite: Animals Idioma: En Revista: Future Med Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Espanha
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Schistosoma mansoni / Esquistossomose / Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 / Descoberta de Drogas / Inibidores da Fosfodiesterase 4 Limite: Animals Idioma: En Revista: Future Med Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Espanha