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The antibody-based delivery of interleukin-12 to solid tumors boosts NK and CD8+ T cell activity and synergizes with immune checkpoint inhibitors.
Puca, Emanuele; Probst, Philipp; Stringhini, Marco; Murer, Patrizia; Pellegrini, Giovanni; Cazzamalli, Samuele; Hutmacher, Cornelia; Gouyou, Baptiste; Wulhfard, Sarah; Matasci, Mattia; Villa, Alessandra; Neri, Dario.
Afiliação
  • Puca E; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland.
  • Probst P; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland.
  • Stringhini M; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland.
  • Murer P; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland.
  • Pellegrini G; Laboratory for Animal Model Pathology, Universität Zürich, Zürich, Switzerland.
  • Cazzamalli S; Philochem AG, Otelfingen, Switzerland.
  • Hutmacher C; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland.
  • Gouyou B; Philochem AG, Otelfingen, Switzerland.
  • Wulhfard S; Philochem AG, Otelfingen, Switzerland.
  • Matasci M; Philochem AG, Otelfingen, Switzerland.
  • Villa A; Philochem AG, Otelfingen, Switzerland.
  • Neri D; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland.
Int J Cancer ; 146(9): 2518-2530, 2020 05 01.
Article em En | MEDLINE | ID: mdl-31374124
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Neoplasias do Colo / Interleucina-12 / Linfócitos T CD8-Positivos / Sinergismo Farmacológico / Antineoplásicos Imunológicos / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Int J Cancer Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Neoplasias do Colo / Interleucina-12 / Linfócitos T CD8-Positivos / Sinergismo Farmacológico / Antineoplásicos Imunológicos / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Int J Cancer Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça