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Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model.
Anthony-Gonda, Kim; Bardhi, Ariola; Ray, Alex; Flerin, Nina; Li, Mengyan; Chen, Weizao; Ochsenbauer, Christina; Kappes, John C; Krueger, Winfried; Worden, Andrew; Schneider, Dina; Zhu, Zhongyu; Orentas, Rimas; Dimitrov, Dimiter S; Goldstein, Harris; Dropulic, Boro.
Afiliação
  • Anthony-Gonda K; Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA.
  • Bardhi A; Department of Microbiology and Immunology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Ray A; Department of Microbiology and Immunology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Flerin N; Department of Microbiology and Immunology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Li M; Department of Microbiology and Immunology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Chen W; Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
  • Ochsenbauer C; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Kappes JC; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Krueger W; Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, AL 35294, USA.
  • Worden A; Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA.
  • Schneider D; Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA.
  • Zhu Z; Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA.
  • Orentas R; Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA.
  • Dimitrov DS; Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA.
  • Goldstein H; Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, PA 15261, USA. boro.dropulic@lentigen.com harris.goldstein@einstein.yu.edu dsd116@pitt.edu.
  • Dropulic B; Department of Microbiology and Immunology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA. boro.dropulic@lentigen.com harris.goldstein@einstein.yu.edu dsd116@pitt.edu.
Sci Transl Med ; 11(504)2019 08 07.
Article em En | MEDLINE | ID: mdl-31391322
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Infecções por HIV / Imunoterapia Adotiva / Receptores de Antígenos Quiméricos Limite: Animals / Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Infecções por HIV / Imunoterapia Adotiva / Receptores de Antígenos Quiméricos Limite: Animals / Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos