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Structure-Based Molecular Networking for the Target Discovery of Oxahomoaporphine and 8-Oxohomoaporphine Alkaloids from Duguetia surinamensis.
Paz, Weider H P; de Oliveira, Rodolfo N; Heerdt, Gabriel; Angolini, Célio F F; S de Medeiros, Lívia; Silva, Valdenizia R; Santos, Luciano S; Soares, Milena B P; Bezerra, Daniel P; Morgon, Nelson H; Almeida, Jackson R G S; da Silva, Felipe M A; Costa, Emmanoel V; Koolen, Hector H F.
Afiliação
  • Paz WHP; Metabolomics and Mass Spectrometry Research Group , Amazonas State University , Manaus 690065-130 , Brazil.
  • de Oliveira RN; Department of Chemistry , Federal University of Amazonas , Manaus 69077-000 , Brazil.
  • Heerdt G; Department of Chemistry , Federal University of Amazonas , Manaus 69077-000 , Brazil.
  • Angolini CFF; Department of Chemistry , Federal University of Minas Gerais , Belo Horizonte 31270-901 , Brazil.
  • S de Medeiros L; Center of Human and Natural Sciences , Federal University of ABC , 09210-580 Santo André , Brazil.
  • Silva VR; Department of Chemistry , Federal University of São Paulo , 09920-540 Diadema , Brazil.
  • Santos LS; Gonçalo Moniz Institute , Oswaldo Cruz Foundation , Salvador 40296-710 , Brazil.
  • Soares MBP; Gonçalo Moniz Institute , Oswaldo Cruz Foundation , Salvador 40296-710 , Brazil.
  • Bezerra DP; Gonçalo Moniz Institute , Oswaldo Cruz Foundation , Salvador 40296-710 , Brazil.
  • Morgon NH; Gonçalo Moniz Institute , Oswaldo Cruz Foundation , Salvador 40296-710 , Brazil.
  • Almeida JRGS; Institute of Chemistry , University of Campinas , Campinas 13083-970 , Brazil.
  • da Silva FMA; Center for Study and Research of Medicinal Plants , Federal University of Vale do São Francisco , Petrolina 56304-205 , Brazil.
  • Costa EV; Department of Chemistry , Federal University of Amazonas , Manaus 69077-000 , Brazil.
  • Koolen HHF; Department of Chemistry , Federal University of Amazonas , Manaus 69077-000 , Brazil.
J Nat Prod ; 82(8): 2220-2228, 2019 08 23.
Article em En | MEDLINE | ID: mdl-31403289
In addition to seven known alkaloids (2, 6-11) and 1,2,4-trimethoxybenzene (1), three isoquinoline-derived alkaloids (3-5), namely, duguetinine (3), a compound based on an unprecedented oxahomoaporphine scaffold, and two new 8-oxohomoaporphine alkaloids, duguesuramine (4) and 11-methoxyduguesuramine (5), and a new asarone-derived phenylpropanoid (10) were isolated from the bark of Duguetia surinamensis. The isolation workflow was guided by HPLC-HRESIMS/MS and molecular networking-based analyses. Twenty-four known alkaloids were dereplicated from the D. surinamensis alkaloid-rich fraction network and were assigned by manual MS/MS interpretation. Their cytotoxic potential was evaluated.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aporfinas / Annonaceae / Alcaloides País/Região como assunto: America do sul / Caribe ingles / Suriname Idioma: En Revista: J Nat Prod Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aporfinas / Annonaceae / Alcaloides País/Região como assunto: America do sul / Caribe ingles / Suriname Idioma: En Revista: J Nat Prod Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil