Stoichiometric gene-to-reaction associations enhance model-driven analysis performance: Metabolic response to chronic exposure to Aldrin in prostate cancer.

Marín de Mas, Igor; Torrents, Laura; Bedia, Carmen; Nielsen, Lars K; Cascante, Marta; Tauler, Romà

Marín de Mas, Igor; Torrents, Laura; Bedia, Carmen; Nielsen, Lars K; Cascante, Marta; Tauler, Romà.

Afiliação

Marín de Mas I; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark. igmar@biosustain.dtu.dk.
Torrents L; Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-24, 08034, Barcelona, Spain. igmar@biosustain.dtu.dk.
Bedia C; Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-24, 08034, Barcelona, Spain.
Nielsen LK; Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-24, 08034, Barcelona, Spain.
Cascante M; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark.
Tauler R; Department of Biochemistry and Molecular Biology, Faculty of Biology, Institute of Biomedicine of University of Barcelona (IBUB), Networked Center for Research in Liver and Digestive Diseases (CIBEREHD- CB17/04/00023)) and metabolomics node at INB-Bioinformatics Platform, Instituto de Salud Carlos I

BMC Genomics ; 20(1): 652, 2019 Aug 15.

Article em En | MEDLINE | ID: mdl-31416420

Assuntos

Aldrina/toxicidade; Disruptores Endócrinos/toxicidade; Neoplasias da Próstata/metabolismo; Carnitina/metabolismo; Linhagem Celular Tumoral; Biologia Computacional; Humanos; Lipidômica; Masculino; Redes e Vias Metabólicas/genética; Modelos Biológicos; Prostaglandinas/biossíntese; Neoplasias da Próstata/química; Neoplasias da Próstata/genética; Transcriptoma

Palavras-chave

Endocrine disruptors; Genome-scale metabolic model; Prostate Cancer; Stoichiometric gene-protein-reaction association; Transcriptomic data integration

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Aldrina / Disruptores Endócrinos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Revista: BMC Genomics Assunto da revista: GENETICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Dinamarca

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