Interplay between Intrinsic and Innate Immunity during HIV Infection.
Cells
; 8(8)2019 08 17.
Article
em En
| MEDLINE
| ID: mdl-31426525
ABSTRACT
Restriction factors are antiviral components of intrinsic immunity which constitute a first line of defense by blocking different steps of the human immunodeficiency virus (HIV) replication cycle. In immune cells, HIV infection is also sensed by several pattern recognition receptors (PRRs), leading to type I interferon (IFN-I) and inflammatory cytokines production that upregulate antiviral interferon-stimulated genes (ISGs). Several studies suggest a link between these two types of immunity. Indeed, restriction factors, that are generally interferon-inducible, are able to modulate immune responses. This review highlights recent knowledge of the interplay between restriction factors and immunity inducing antiviral defenses. Counteraction of this intrinsic and innate immunity by HIV viral proteins will also be discussed.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Interferon Tipo I
/
Infecções por HIV
/
HIV-1
/
Fatores Reguladores de Interferon
/
Receptores de Reconhecimento de Padrão
/
Interações entre Hospedeiro e Microrganismos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cells
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
França