Effects of diamine oxidase inhibition during pregnancy in the rat.
Rev Esp Fisiol
; 44(2): 131-5, 1988 Jun.
Article
em En
| MEDLINE
| ID: mdl-3143132
ABSTRACT
The effects of inhibiting histamine catabolism, via oxidative deamination, on the course of pregnancy on rats and on their offspring were studied. Treatment with aminoguanidine, a potent inhibitor of diamine oxidase (EC 1.4.3.6), was performed during pregnancy, before histamine levels were spontaneously increased. Twenty-one day old fetuses from treated rats showed head, lung and liver hematomas with significant differences. Abnormalities of ossification were also recorded in bones of the cranial cavity, with different statistical significances. The results of the present experiment confirm that oxidative deamination is the main catabolic pathway for histamine in the rat. Organic and skeletal abnormalities found also suggest that diamine oxidase protects fetuses from histamine excesses attained during pregnancy.
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Base de dados:
MEDLINE
Assunto principal:
Anormalidades Induzidas por Medicamentos
/
Prenhez
/
Histamina
/
Amina Oxidase (contendo Cobre)
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Rev Esp Fisiol
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Espanha