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Pursuing Human-Relevant Gut Microbiota-Immune Interactions.
Spencer, Sean P; Fragiadakis, Gabriela K; Sonnenburg, Justin L.
Afiliação
  • Spencer SP; Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
  • Fragiadakis GK; Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA. Electronic address: gabif@stanford.edu.
  • Sonnenburg JL; Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA; Center for Human Microbiome Studies, Stanford University, Stanford, CA, USA. Electronic address: jsonnenburg@stanford.edu.
Immunity ; 51(2): 225-239, 2019 08 20.
Article em En | MEDLINE | ID: mdl-31433970
The gut microbiota is a complex and plastic network of diverse organisms intricately connected with human physiology. Recent advances in profiling approaches of both the microbiota and the immune system now enable a deeper exploration of immunity-microbiota connections. An important next step is to elucidate a human-relevant "map" of microbial-immune wiring while focusing on animal studies to probe a prioritized subset of interactions. Here, we provide an overview of this field's current status and discuss two approaches for establishing priorities for detailed investigation: (1) longitudinal intervention studies in humans probing the dynamics of both the microbiota and the immune system and (2) the study of traditional populations to assess lost features of human microbial identity whose absence may be contributing to the rise of immunological disorders. These human-centered approaches offer a judicious path forward to understand the impact of the microbiota in immune development and function.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interações Hospedeiro-Patógeno / Microbioma Gastrointestinal / Sistema Imunitário Limite: Animals / Humans Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interações Hospedeiro-Patógeno / Microbioma Gastrointestinal / Sistema Imunitário Limite: Animals / Humans Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos