Sustained delivery of anti-VEGFs from thermogel depots inhibits angiogenesis without the need for multiple injections.

Xue, Kun; Zhao, Xinxin; Zhang, Zhongxing; Qiu, Beiying; Tan, Queenie Shu Woon; Ong, Kok Haur; Liu, Zengping; Parikh, Bhav Harshad; Barathi, Veluchamy Amutha; Yu, Weimiao; Wang, Xiaomeng; Lingam, Gopal; Hunziker, Walter; Su, Xinyi; Loh, Xian Jun

Xue, Kun; Zhao, Xinxin; Zhang, Zhongxing; Qiu, Beiying; Tan, Queenie Shu Woon; Ong, Kok Haur; Liu, Zengping; Parikh, Bhav Harshad; Barathi, Veluchamy Amutha; Yu, Weimiao; Wang, Xiaomeng; Lingam, Gopal; Hunziker, Walter; Su, Xinyi; Loh, Xian Jun.

Afiliação

Xue K; Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, #08-03 Innovis, Singapore 138634, Singapore. lohxj@imre.a-star.edu.sg.
Zhao X; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive Proteos, Singapore 138673, Singapore. xysu@imcb.a-star.edu.sg.
Zhang Z; Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, #08-03 Innovis, Singapore 138634, Singapore. lohxj@imre.a-star.edu.sg.
Qiu B; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive Proteos, Singapore 138673, Singapore. xysu@imcb.a-star.edu.sg.
Tan QSW; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive Proteos, Singapore 138673, Singapore. xysu@imcb.a-star.edu.sg.
Ong KH; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive Proteos, Singapore 138673, Singapore. xysu@imcb.a-star.edu.sg.
Liu Z; Department of Ophthalmology, Yong Loo Lin School of Medicine, National, University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 7, Singapore 119228 and Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751, Singapore.
Parikh BH; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive Proteos, Singapore 138673, Singapore. xysu@imcb.a-star.edu.sg and Department of Ophthalmology, Yong Loo Lin School of Medicine, National, University of Singapore, 1E Kent Ridge Roa
Barathi VA; Department of Ophthalmology, Yong Loo Lin School of Medicine, National, University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 7, Singapore 119228 and Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751, Singapore and Academic Clinical Program in Ophthalmology,
Yu W; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive Proteos, Singapore 138673, Singapore. xysu@imcb.a-star.edu.sg.
Wang X; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive Proteos, Singapore 138673, Singapore. xysu@imcb.a-star.edu.sg and Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751, Singapore and Lee Kong Chian School
Lingam G; Department of Ophthalmology, Yong Loo Lin School of Medicine, National, University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 7, Singapore 119228.
Hunziker W; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive Proteos, Singapore 138673, Singapore. xysu@imcb.a-star.edu.sg.
Su X; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive Proteos, Singapore 138673, Singapore. xysu@imcb.a-star.edu.sg and Department of Ophthalmology, Yong Loo Lin School of Medicine, National, University of Singapore, 1E Kent Ridge Roa
Loh XJ; Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, #08-03 Innovis, Singapore 138634, Singapore. lohxj@imre.a-star.edu.sg and Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751, Singapore and Depa

Biomater Sci ; 7(11): 4603-4614, 2019 Nov 01.

Article em En | MEDLINE | ID: mdl-31436780

Assuntos

Inibidores da Angiogênese/farmacologia; Sistemas de Liberação de Medicamentos; Neovascularização Patológica/tratamento farmacológico; Poliuretanos/farmacologia; Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores; Ácido 2-Aminoadípico; Inibidores da Angiogênese/administração & dosagem; Inibidores da Angiogênese/química; Animais; Humanos; Injeções Intravítreas; Camundongos; Camundongos Endogâmicos C57BL; Neovascularização Patológica/induzido quimicamente; Poliuretanos/administração & dosagem; Poliuretanos/química; Coelhos; Ratos; Fator A de Crescimento do Endotélio Vascular/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poliuretanos / Sistemas de Liberação de Medicamentos / Inibidores da Angiogênese / Fator A de Crescimento do Endotélio Vascular / Neovascularização Patológica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Biomater Sci Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Singapura

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