Green Method To Preparing Oxindole-Fused Spirotetrahydrofuran Scaffolds through Methanesulfonic Acid-Catalyzed Cyclization Reactions of 3-Allyl-3-hydroxy-2-oxindole in Water.
ACS Omega
; 2(10): 7022-7028, 2017 Oct 31.
Article
em En
| MEDLINE
| ID: mdl-31457284
ABSTRACT
Water is an ideal solvent for chemical transformations in environmentally friendly and sustainable processes. An operationally simple, metal-free, and green approach to the synthesis of oxindole-fused spirotetrahydrofurans from 3-allyl-3-hydroxy-2-oxindoles in water is described. This method requires only cheap methanesulfonic acid as a catalyst and eliminates the need of complicated reagents. This atom- and step-economical transformation is highly efficient, which provides a new approach for the construction of oxindole-fused spirotetrahydrofuran molecules with potential pharmaceutical interest.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
ACS Omega
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
China