Human blood-based exposure levels of persistent organic pollutant (POP) mixtures antagonise androgen receptor transactivation and translocation.

McComb, J; Mills, I G; Muller, M; Berntsen, H F; Zimmer, K E; Ropstad, E; Verhaegen, S; Connolly, L

McComb, J; Mills, I G; Muller, M; Berntsen, H F; Zimmer, K E; Ropstad, E; Verhaegen, S; Connolly, L.

Afiliação

McComb J; Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast BT9 5DL, Northern Ireland, United Kingdom.
Mills IG; Prostate Cancer UK/Movember Centre of Excellence, Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry, and Biomedical Sciences, Queen's University Belfast, Belfast BT9 7AE, Northern Ireland, United Kingdom; Nuffield Department of Surgical Sciences, University of Oxford, Level
Muller M; Laboratory for Organogenesis and Regeneration, GIGA-Research, University of Liège, Liège 4000, Belgium.
Berntsen HF; Department of Production Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Post-box 369 sentrum, 0102 Oslo, Norway; Department of Administration, Lab Animal Unit, National Institute of Occupational Health, P.O. Box 5330, Oslo, Norway.
Zimmer KE; Department of Basic Sciences and Aquatic Medicine, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Post-box 369 sentrum, 0102 Oslo, Norway.
Ropstad E; Department of Production Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Post-box 369 sentrum, 0102 Oslo, Norway.
Verhaegen S; Department of Production Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Post-box 369 sentrum, 0102 Oslo, Norway.
Connolly L; Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast BT9 5DL, Northern Ireland, United Kingdom. Electronic address: l.connolly@qub.ac.uk.

Environ Int ; 132: 105083, 2019 11.

Article em En | MEDLINE | ID: mdl-31470217

Assuntos

Antagonistas de Receptores de Andrógenos/sangue; Disruptores Endócrinos/sangue; Poluentes Ambientais/sangue; Poluentes Ambientais/toxicidade; Receptores Androgênicos; Ativação Transcricional/efeitos dos fármacos; Antagonistas de Receptores de Andrógenos/toxicidade; Células Cultivadas; Disruptores Endócrinos/toxicidade; Genes Reporter; Humanos; Testosterona/farmacologia; Translocação Genética/efeitos dos fármacos

Palavras-chave

Androgen receptor; Cocktail effect; Endocrine disrupting chemical; High content screening; Mixture; Persistent organic pollutant

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Androgênicos / Ativação Transcricional / Poluentes Ambientais / Disruptores Endócrinos / Antagonistas de Receptores de Andrógenos Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Environ Int Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido

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