Critical review of the association between perineal use of talc powder and risk of ovarian cancer.
Reprod Toxicol
; 90: 88-101, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-31472245
ABSTRACT
Over the past four decades, there has been increasing concern that perineal use of talc powder, a commonly used personal care product, might be associated with an increased risk of ovarian cancer. OBJECTIVES:
To critically review all available human epidemiological data on the relationship between perineal use of talc powder and ovarian cancer, with consideration of other relevant experimental evidence.METHODOLOGY:
We identified 30 human studies for qualitative assessment of evidence, including 27 that were retained for further quantitative analysis.RESULTS:
A positive association between perineal use of talc powder and ovarian cancer was found [OR 1.28 (95% CI 1.20-1.37)]. A significant risk was noted in Hispanics and Whites, in women applying talc to underwear, in pre-menopausal women and in post-menopausal women receiving hormonal therapy. A negative association was noted with tubal ligation.CONCLUSION:
Perineal use of talc powder is a possible cause of human ovarian cancer.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Períneo
/
Talco
Tipo de estudo:
Etiology_studies
/
Qualitative_research
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Reprod Toxicol
Assunto da revista:
EMBRIOLOGIA
/
MEDICINA REPRODUTIVA
/
TOXICOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article