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Critical review of the association between perineal use of talc powder and risk of ovarian cancer.
Kadry Taher, Mohamed; Farhat, Nawal; Karyakina, Nataliya A; Shilnikova, Nataliya; Ramoju, Siva; Gravel, Christopher A; Krishnan, Kannan; Mattison, Donald; Wen, Shi-Wu; Krewski, Daniel.
Afiliação
  • Kadry Taher M; Risk Sciences International, 251 Laurier Ave W, Suite 700, Ottawa, ON, K1P 5J6, Canada; McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada; School of Epidemiology and Public Health, University of
  • Farhat N; Risk Sciences International, 251 Laurier Ave W, Suite 700, Ottawa, ON, K1P 5J6, Canada; McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada; School of Epidemiology and Public Health, University of
  • Karyakina NA; Risk Sciences International, 251 Laurier Ave W, Suite 700, Ottawa, ON, K1P 5J6, Canada; McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada.
  • Shilnikova N; Risk Sciences International, 251 Laurier Ave W, Suite 700, Ottawa, ON, K1P 5J6, Canada; McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada.
  • Ramoju S; Risk Sciences International, 251 Laurier Ave W, Suite 700, Ottawa, ON, K1P 5J6, Canada.
  • Gravel CA; McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada; School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada; Department of Epidemiolo
  • Krishnan K; Risk Sciences International, 251 Laurier Ave W, Suite 700, Ottawa, ON, K1P 5J6, Canada.
  • Mattison D; Risk Sciences International, 251 Laurier Ave W, Suite 700, Ottawa, ON, K1P 5J6, Canada; McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada; School of Epidemiology and Public Health, University of
  • Wen SW; School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada; OMNI Research Group, Department of Obstetrics and Gynaecology, University of Ottawa Faculty of Medicine, Ottawa, ON, Canada; Clinical Epidemiology Program, Ottawa Hospital Research
  • Krewski D; Risk Sciences International, 251 Laurier Ave W, Suite 700, Ottawa, ON, K1P 5J6, Canada; McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada; School of Epidemiology and Public Health, University of
Reprod Toxicol ; 90: 88-101, 2019 12.
Article em En | MEDLINE | ID: mdl-31472245
ABSTRACT
Over the past four decades, there has been increasing concern that perineal use of talc powder, a commonly used personal care product, might be associated with an increased risk of ovarian cancer.

OBJECTIVES:

To critically review all available human epidemiological data on the relationship between perineal use of talc powder and ovarian cancer, with consideration of other relevant experimental evidence.

METHODOLOGY:

We identified 30 human studies for qualitative assessment of evidence, including 27 that were retained for further quantitative analysis.

RESULTS:

A positive association between perineal use of talc powder and ovarian cancer was found [OR 1.28 (95% CI 1.20-1.37)]. A significant risk was noted in Hispanics and Whites, in women applying talc to underwear, in pre-menopausal women and in post-menopausal women receiving hormonal therapy. A negative association was noted with tubal ligation.

CONCLUSION:

Perineal use of talc powder is a possible cause of human ovarian cancer.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Períneo / Talco Tipo de estudo: Etiology_studies / Qualitative_research / Risk_factors_studies / Systematic_reviews Limite: Animals / Female / Humans Idioma: En Revista: Reprod Toxicol Assunto da revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Períneo / Talco Tipo de estudo: Etiology_studies / Qualitative_research / Risk_factors_studies / Systematic_reviews Limite: Animals / Female / Humans Idioma: En Revista: Reprod Toxicol Assunto da revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article