Differences in Biomarkers Pattern Between Severe Isolated Right and Left Ventricular Dysfunction After Cardiac Surgery.
J Cardiothorac Vasc Anesth
; 34(3): 650-658, 2020 Mar.
Article
em En
| MEDLINE
| ID: mdl-31473115
ABSTRACT
OBJECTIVE:
To find out if there are any differences in biomarkers between severe isolated right ventricular (RV) dysfunction and severe isolated left ventricular (LV) dysfunction after cardiac surgery using cardiopulmonary bypass.DESIGN:
Observational study.SETTING:
Teaching hospital.PARTICIPANTS:
A total of 46 patients who had severe isolated RV or LV dysfunction after cardiac surgery. INTERVENTION The authors collected perioperative clinical and biomarker data. MEASUREMENTS AND MAINRESULTS:
Severe isolated RV dysfunction patients (nâ¯=â¯20) had higher postoperative direct bilirubin (pâ¯=â¯0.030), total bilirubin (pâ¯=â¯0.044), glucose (pâ¯=â¯0.011), and international normalized ratio (INR) (pâ¯=â¯0.050) by repeated measure analysis of variance when compared with patients with severe isolated LV dysfunction (nâ¯=â¯26). The RV group also showed lower preoperative alanine transferase (19.3 ± 1.5 v 32.7 ± 4.2, pâ¯=â¯0.001), higher 4-hour INR (1.5 ± 0.3 v 1.4 ± 0.2, pâ¯=â¯0.008), and higher 48-hour INR (1.8 ± 0.4 v 1.4 ± 0.1, p < 0.001). None in the LV group died, whereas 4 patients in the RV group died (all of them had preoperative atrial fibrillation and underwent double valve replacement surgery).CONCLUSION:
The authors observed biomarkers differences between severe isolated RV dysfunction and severe isolated RV dysfunction.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Disfunção Ventricular Direita
/
Disfunção Ventricular Esquerda
/
Procedimentos Cirúrgicos Cardíacos
Tipo de estudo:
Etiology_studies
/
Observational_studies
Limite:
Humans
Idioma:
En
Revista:
J Cardiothorac Vasc Anesth
Assunto da revista:
ANESTESIOLOGIA
/
CARDIOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Itália