A Nasal Temperature and pH Dual-Responsive In Situ Gel Delivery System Based on Microemulsion of Huperzine A: Formulation, Evaluation, and In Vivo Pharmacokinetic Study.

Chen, Yifan; Cheng, Gang; Hu, Rongfeng; Chen, Shengqi; Lu, Wenjie; Gao, Song; Xia, Hongmei; Wang, Bin; Sun, Chaojie; Nie, Xiangjiang; Shen, Qiang; Fang, Wenyou

Chen, Yifan; Cheng, Gang; Hu, Rongfeng; Chen, Shengqi; Lu, Wenjie; Gao, Song; Xia, Hongmei; Wang, Bin; Sun, Chaojie; Nie, Xiangjiang; Shen, Qiang; Fang, Wenyou.

Afiliação

Chen Y; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, Anhui, 230038, People's Republic of China.
Cheng G; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, Anhui, 230038, People's Republic of China.
Hu R; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, Anhui, 230038, People's Republic of China. rongfenghu2003@hotmail.com.
Chen S; Anhui Province Key Laboratory of Chinese Medicinal Formula, Anhui University of Chinese Medicine, Hefei, Anhui, 230012, People's Republic of China. rongfenghu2003@hotmail.com.
Lu W; Anhui Province Key Laboratory of R&D of Chinese Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, 230038, People's Republic of China. rongfenghu2003@hotmail.com.
Gao S; Anhui "115" Xin'an Traditional Chinese Medical Research & Development Innovation Team, Hefei, Anhui, 230038, People's Republic of China. rongfenghu2003@hotmail.com.
Xia H; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, Anhui, 230038, People's Republic of China.
Wang B; School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 210009, People's Republic of China.
Sun C; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, Anhui, 230038, People's Republic of China.
Nie X; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, Anhui, 230038, People's Republic of China.
Shen Q; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, Anhui, 230038, People's Republic of China.
Fang W; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, Anhui, 230038, People's Republic of China.

AAPS PharmSciTech ; 20(7): 301, 2019 Sep 04.

Article em En | MEDLINE | ID: mdl-31485857

Assuntos

Alcaloides/administração & dosagem; Inibidores da Colinesterase/administração & dosagem; Sistemas de Liberação de Medicamentos; Sesquiterpenos/administração & dosagem; Administração Intranasal; Alcaloides/química; Alcaloides/farmacocinética; Animais; Encéfalo/efeitos dos fármacos; Composição de Medicamentos; Emulsões; Géis; Concentração de Íons de Hidrogênio; Masculino; Ratos; Ratos Sprague-Dawley; Sesquiterpenos/química; Sesquiterpenos/farmacocinética; Temperatura

Palavras-chave

dual-responsive in situ gel; huperzine A; microdialysis; microemulsion; nasal administration

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Inibidores da Colinesterase / Sistemas de Liberação de Medicamentos / Alcaloides Limite: Animals Idioma: En Revista: AAPS PharmSciTech Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article

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