Fibrillation of human islet amyloid polypeptide and its toxicity to pancreatic ß-cells under lipid environment.

Gao, Li-Ping; Chen, Hai-Chao; Ma, Ze-Lin; Chen, An-Di; Du, Hong-Li; Yin, Jie; Jing, Yu-Hong

Gao, Li-Ping; Chen, Hai-Chao; Ma, Ze-Lin; Chen, An-Di; Du, Hong-Li; Yin, Jie; Jing, Yu-Hong.

Afiliação

Gao LP; Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou City, Gansu province 730000, People's Republic of China.
Chen HC; Institute of Anatomy and Histology & Embryology, Neuroscience, School of Basic Medical Sciences, Lanzhou University, Lanzhou City, Gansu Province 730000, People's Republic of China.
Ma ZL; Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou City, Gansu province 730000, People's Republic of China.
Chen AD; Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou City, Gansu province 730000, People's Republic of China.
Du HL; Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou City, Gansu province 730000, People's Republic of China.
Yin J; Institute of Anatomy and Histology & Embryology, Neuroscience, School of Basic Medical Sciences, Lanzhou University, Lanzhou City, Gansu Province 730000, People's Republic of China.
Jing YH; Institute of Anatomy and Histology & Embryology, Neuroscience, School of Basic Medical Sciences, Lanzhou University, Lanzhou City, Gansu Province 730000, People's Republic of China; Key Laboratory of Preclinical Study for New Drugs of Gansu province, Lanzhou University, Lanzhou City, Gansu Provi

Biochim Biophys Acta Gen Subj ; 1864(1): 129422, 2020 01.

Article em En | MEDLINE | ID: mdl-31491457

Assuntos

Apoptose/genética; Fibrose/genética; Células Secretoras de Insulina/metabolismo; Polipeptídeo Amiloide das Ilhotas Pancreáticas/genética; Amiloide/genética; Amiloide/metabolismo; Membrana Celular/genética; Membrana Celular/metabolismo; Estresse do Retículo Endoplasmático/genética; Ácidos Graxos não Esterificados/genética; Ácidos Graxos não Esterificados/metabolismo; Fibrose/metabolismo; Fibrose/patologia; Regulação da Expressão Gênica/genética; Humanos; Células Secretoras de Insulina/patologia; Polipeptídeo Amiloide das Ilhotas Pancreáticas/metabolismo; Polipeptídeo Amiloide das Ilhotas Pancreáticas/ultraestrutura; Metabolismo dos Lipídeos/genética; Lipídeos/genética; Ácido Palmítico/metabolismo; Fosfatidilcolinas/genética; Fosfatidilcolinas/metabolismo; Fosfatidilserinas/genética; Fosfatidilserinas/metabolismo; Conformação Proteica em Folha beta; Dobramento de Proteína

Palavras-chave

Endoplasmic reticulum stress; Human islet amyloid polypeptide conformation; Lipid condition; Pancreatic islet ß cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose / Apoptose / Células Secretoras de Insulina / Polipeptídeo Amiloide das Ilhotas Pancreáticas Limite: Humans Idioma: En Revista: Biochim Biophys Acta Gen Subj Ano de publicação: 2020 Tipo de documento: Article

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