Phosphorylation of the HCN channel auxiliary subunit TRIP8b is altered in an animal model of temporal lobe epilepsy and modulates channel function.

Foote, Kendall M; Lyman, Kyle A; Han, Ye; Michailidis, Ioannis E; Heuermann, Robert J; Mandikian, Danielle; Trimmer, James S; Swanson, Geoffrey T; Chetkovich, Dane M

Foote, Kendall M; Lyman, Kyle A; Han, Ye; Michailidis, Ioannis E; Heuermann, Robert J; Mandikian, Danielle; Trimmer, James S; Swanson, Geoffrey T; Chetkovich, Dane M.

Afiliação

Foote KM; Davee Department of Neurology and Clinical Neurosciences, Northwestern University, Chicago, Illinois 60611.
Lyman KA; Department of Pharmacology, Northwestern University, Chicago, Illinois 60611.
Han Y; Vanderbilt University Medical Center Department of Neurology, Nashville, Tennessee 37232.
Michailidis IE; Davee Department of Neurology and Clinical Neurosciences, Northwestern University, Chicago, Illinois 60611.
Heuermann RJ; Vanderbilt University Medical Center Department of Neurology, Nashville, Tennessee 37232.
Mandikian D; Department of Medicine, Stanford University, Palo Alto, California 94305.
Trimmer JS; Davee Department of Neurology and Clinical Neurosciences, Northwestern University, Chicago, Illinois 60611.
Swanson GT; Vanderbilt University Medical Center Department of Neurology, Nashville, Tennessee 37232.
Chetkovich DM; Vanderbilt University Medical Center Department of Neurology, Nashville, Tennessee 37232.

J Biol Chem ; 294(43): 15743-15758, 2019 10 25.

Article em En | MEDLINE | ID: mdl-31492750

Assuntos

Epilepsia do Lobo Temporal/metabolismo; Proteínas de Membrana/metabolismo; Peroxinas/metabolismo; Subunidades Proteicas/metabolismo; Sequência de Aminoácidos; Animais; Encéfalo/metabolismo; Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/metabolismo; Dendritos/metabolismo; Modelos Animais de Doenças; Feminino; Células HEK293; Humanos; Ativação do Canal Iônico; Ácido Caínico; Proteínas de Membrana/química; Camundongos Endogâmicos C57BL; Peroxinas/química; Fosforilação; Fosfosserina/metabolismo; Subunidades Proteicas/química; Ratos Sprague-Dawley; Reprodutibilidade dos Testes

Palavras-chave

Ca2+/calmodulin-dependent protein kinase II (CaMKII); HCN; TLE; TRIP8b; channelopathy; epilepsy; ion channel; neuronal excitability; phosphorylation; proteinprotein interaction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Subunidades Proteicas / Epilepsia do Lobo Temporal / Peroxinas / Proteínas de Membrana Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article

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