MCI-to-normal reversion using neuropsychological criteria in the Alzheimer's Disease Neuroimaging Initiative.
Alzheimers Dement
; 15(10): 1322-1332, 2019 10.
Article
em En
| MEDLINE
| ID: mdl-31495605
ABSTRACT
INTRODUCTION:
The low mild cognitive impairment (MCI) to cognitively normal (CN) reversion rate in the Alzheimer's Disease Neuroimaging Initiative (2-3%) suggests the need to examine reversion by other means. We applied comprehensive neuropsychological criteria (NP criteria) to determine the resulting MCI to CN reversion rate.METHODS:
Participants with CN (n = 641) or MCI (n = 569) were classified at baseline and year 1 using NP criteria. Demographic, neuropsychological, and Alzheimer's disease biomarker variables as well as progression to dementia were examined across stable CN, reversion, and stable MCI groups.RESULTS:
NP criteria produced a one-year reversion rate of 15.8%. Reverters had demographics, Alzheimer's disease biomarkers, and risk-of-progression most similar to the stable CN group and showed the most improvement on neuropsychological measures from baseline to year 1.DISCUSSION:
NP criteria produced a reversion rate that is consistent with, albeit modestly improved from, reversion rates in meta-analyses. Reverters' biomarker profiles and progression rates suggest that NP criteria accurately tracked with underlying pathophysiologic status.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Cognição
/
Neuroimagem
/
Disfunção Cognitiva
/
Testes Neuropsicológicos
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
Idioma:
En
Revista:
Alzheimers Dement
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos