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Nectriatide, a Potentiator of Amphotericin B Activity from Nectriaceae sp. BF-0114.
Fukuda, Takashi; Nagai, Kenichiro; Yagi, Akiho; Kobayashi, Keisuke; Uchida, Ryuji; Yasuhara, Tadashi; Tomoda, Hiroshi.
Afiliação
  • Fukuda T; Microbial Chemistry and Medicinal Research Laboratories, Graduate School of Pharmaceutical Sciences , Kitasato University , 5-9-1 Shirokane , Minato-ku, Tokyo 108-8641 , Japan.
  • Nagai K; Department of Fisheries, Faculty of Agriculture and Agricultural Technology and Innovation Research Institute , Kindai University , 3327-204 Nakamachi , Nara 631-8505 , Japan.
  • Yagi A; Microbial Chemistry and Medicinal Research Laboratories, Graduate School of Pharmaceutical Sciences , Kitasato University , 5-9-1 Shirokane , Minato-ku, Tokyo 108-8641 , Japan.
  • Kobayashi K; Department of Natural Product Chemistry , Tohoku Medical and Pharmaceutical University , 4-4-1 Komatsushima , Aoba-ku, Sendai, Miyagi 981-8558 , Japan.
  • Uchida R; Microbial Chemistry and Medicinal Research Laboratories, Graduate School of Pharmaceutical Sciences , Kitasato University , 5-9-1 Shirokane , Minato-ku, Tokyo 108-8641 , Japan.
  • Yasuhara T; Department of Natural Product Chemistry , Tohoku Medical and Pharmaceutical University , 4-4-1 Komatsushima , Aoba-ku, Sendai, Miyagi 981-8558 , Japan.
  • Tomoda H; Microbial Chemistry and Medicinal Research Laboratories, Graduate School of Pharmaceutical Sciences , Kitasato University , 5-9-1 Shirokane , Minato-ku, Tokyo 108-8641 , Japan.
J Nat Prod ; 82(10): 2673-2681, 2019 10 25.
Article em En | MEDLINE | ID: mdl-31498627
A new compound, designated nectriatide (1), was isolated as a potentiator of amphotericin B (AmB) activity against Candida albicans from the culture broth of Nectriaceae sp. BF-0114. This structure was elucidated based on spectroscopic analyses (1D and 2D NMR data), chemical methods, and total synthesis. Compound 1 was a unique cyclotetrapeptide consisting of l-N-methyltyrosine, anthranilic acid, l-alanine, and l-valine. Compound 1 and several synthetic derivatives, including linear peptides, potentiated AmB activity against C. albicans by up to 16-fold (the MIC value of AmB decreased from 0.5 µg/mL to 0.031 µg/mL in combination with test compound).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anfotericina B / Hypocreales / Antifúngicos Idioma: En Revista: J Nat Prod Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anfotericina B / Hypocreales / Antifúngicos Idioma: En Revista: J Nat Prod Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão