Pathogenic CD8+ Epidermis-Resident Memory T Cells Displace Dendritic Epidermal T Cells in Allergic Dermatitis.
J Invest Dermatol
; 140(4): 806-815.e5, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-31518559
ABSTRACT
The skin is our interface with the outside world, and consequently it is exposed to a wide range of microbes and allergens. Recent studies have indicated that allergen-specific skin-resident memory T (TRM) cells play a role in allergic contact dermatitis (ACD). However, the composition and dynamics of the epidermal T-cell subsets during ACD are not known. Here we show that exposure of the skin to the experimental contact allergen DNFB results in a displacement of the normally occurring dendritic epidermal T cells (DETC) concomitant with an accumulation of epidermal CD8+CD69+CD103+ TRM cells in mice. By studying knockout mice, we provide evidence that CD8+ T cells are required for the displacement of the DETC and that DETC are not required for recruitment of CD8+ TRM cells to the epidermis following allergen exposure. We demonstrate that the magnitude of the allergic reaction correlates with the number of CD8+ epidermal TRM cells, which again correlates with allergen dose and number of allergen exposures. Finally, in an attempt to elucidate why CD8+ epidermal TRM cells persist in the epidermis, we show that CD8+ epidermal TRM cells have a higher proliferative capability and are bioenergetically more stable, displaying a higher spare respiratory capacity than DETC.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
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Dermatite Alérgica de Contato
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Linfócitos T CD8-Positivos
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Memória Imunológica
Limite:
Animals
Idioma:
En
Revista:
J Invest Dermatol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Dinamarca