"Too much guts and not enough brains": (epi)genetic mechanisms and future therapies of Hirschsprung disease - a review.

Jaroy, Emilie G; Acosta-Jimenez, Lourdes; Hotta, Ryo; Goldstein, Allan M; Emblem, Ragnhild; Klungland, Arne; Ougland, Rune

Jaroy, Emilie G; Acosta-Jimenez, Lourdes; Hotta, Ryo; Goldstein, Allan M; Emblem, Ragnhild; Klungland, Arne; Ougland, Rune.

Afiliação

Jaroy EG; Clinic for Diagnostics and Intervention and Institute of Medical Microbiology, Oslo University Hospital, Rikshospitalet, 0027, Oslo, Norway.
Acosta-Jimenez L; Department of Pediatric Surgery, Oslo University Hospital, Rikshospitalet, 0424, Oslo, Norway.
Hotta R; Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, 0317, Oslo, Norway.
Goldstein AM; Clinic for Diagnostics and Intervention and Institute of Medical Microbiology, Oslo University Hospital, Rikshospitalet, 0027, Oslo, Norway.
Emblem R; Department of Pediatric Surgery, Oslo University Hospital, Rikshospitalet, 0424, Oslo, Norway.
Klungland A; Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, 0317, Oslo, Norway.
Ougland R; Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Clin Epigenetics ; 11(1): 135, 2019 09 13.

Article em En | MEDLINE | ID: mdl-31519213

Assuntos

Epigênese Genética; Doença de Hirschsprung/genética; Metilação de DNA; Regulação da Expressão Gênica; Doença de Hirschsprung/terapia; Humanos; MicroRNAs/genética

Palavras-chave

Cell therapy; Development; Enteric nervous system; Epigenetics; HSCR; Hirschsprung; Neural crest

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Epigênese Genética / Doença de Hirschsprung Limite: Humans Idioma: En Revista: Clin Epigenetics Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Noruega

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