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Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.
Jackstadt, Rene; van Hooff, Sander R; Leach, Joshua D; Cortes-Lavaud, Xabier; Lohuis, Jeroen O; Ridgway, Rachel A; Wouters, Valérie M; Roper, Jatin; Kendall, Timothy J; Roxburgh, Campbell S; Horgan, Paul G; Nixon, Colin; Nourse, Craig; Gunzer, Matthias; Clark, William; Hedley, Ann; Yilmaz, Omer H; Rashid, Mamunur; Bailey, Peter; Biankin, Andrew V; Campbell, Andrew D; Adams, David J; Barry, Simon T; Steele, Colin W; Medema, Jan Paul; Sansom, Owen J.
Afiliação
  • Jackstadt R; Cancer Research UK Beatson Institute, Glasgow, UK.
  • van Hooff SR; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands; Oncode Institute, Amsterdam, the Netherlands.
  • Leach JD; Cancer Research UK Beatson Institute, Glasgow, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK.
  • Cortes-Lavaud X; Cancer Research UK Beatson Institute, Glasgow, UK.
  • Lohuis JO; Cancer Research UK Beatson Institute, Glasgow, UK.
  • Ridgway RA; Cancer Research UK Beatson Institute, Glasgow, UK.
  • Wouters VM; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands; Oncode Institute, Amsterdam, the Netherlands.
  • Roper J; Department of Medicine, Division of Gastroenterology, Duke University, Durham, NC, USA.
  • Kendall TJ; Division of Pathology/Centre for Inflammation Research, University of Edinburgh, UK.
  • Roxburgh CS; Academic Unit of Surgery, School of Medicine, University of Glasgow, Glasgow, UK.
  • Horgan PG; Academic Unit of Surgery, School of Medicine, University of Glasgow, Glasgow, UK.
  • Nixon C; Cancer Research UK Beatson Institute, Glasgow, UK.
  • Nourse C; Cancer Research UK Beatson Institute, Glasgow, UK.
  • Gunzer M; Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Clark W; Cancer Research UK Beatson Institute, Glasgow, UK.
  • Hedley A; Cancer Research UK Beatson Institute, Glasgow, UK.
  • Yilmaz OH; Division of Gastroenterology, Tufts Medical Center, Boston, MA, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
  • Rashid M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • Bailey P; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK.
  • Biankin AV; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK.
  • Campbell AD; Cancer Research UK Beatson Institute, Glasgow, UK.
  • Adams DJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • Barry ST; Bioscience, Oncology R&D, AstraZeneca, Cambridge, UK.
  • Steele CW; Cancer Research UK Beatson Institute, Glasgow, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK.
  • Medema JP; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands; Oncode Institute, Amsterdam, the Netherlands.
  • Sansom OJ; Cancer Research UK Beatson Institute, Glasgow, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK. Electronic address: o.sansom@beatson.gla.ac.uk.
Cancer Cell ; 36(3): 319-336.e7, 2019 09 16.
Article em En | MEDLINE | ID: mdl-31526760
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Regulação Neoplásica da Expressão Gênica / Receptor Notch1 / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Regulação Neoplásica da Expressão Gênica / Receptor Notch1 / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido