Monthly variance in UK renal transplantation activity: a national retrospective cohort study.
BMJ Open
; 9(9): e028786, 2019 09 17.
Article
em En
| MEDLINE
| ID: mdl-31530596
ABSTRACT
OBJECTIVE:
To identify whether renal transplant activity varies in a reproducible manner across the year.DESIGN:
Retrospective cohort study using NHS Blood and Transplant data.SETTING:
All renal transplant centres in the UK.PARTICIPANTS:
A total of 24 270 patients who underwent renal transplantation between 2005 and 2014. PRIMARYOUTCOME:
Monthly transplant activity was analysed to see if transplant activity showed variation during the year. SECONDARYOUTCOME:
The number of organs rejected due to healthcare capacity was analysed to see if this affected transplantation rates.RESULTS:
Analysis of national transplant data revealed a reproducible yearly variance in transplant activity. This activity increased in late autumn and early winter (p=0.05) and could be attributed to increased rates of living (October and November) and deceased organ donation (November and December). An increase in deceased donation was attributed to a rise in donors following cerebrovascular accidents and hypoxic brain injury. Other causes of death (infections and road traffic accidents) were more seasonal in nature peaking in the winter or summer, respectively. Only 1.4% of transplants to intended recipients were redirected due to a lack of healthcare capacity, suggesting that capacity pressures in the National Health Service did not significantly affect transplant activity.CONCLUSION:
UK renal transplant activity peaks in late autumn/winter in contrast to other countries. Currently, healthcare capacity, though under strain, does not affect transplant activity; however, this may change if transplantation activity increases in line with national strategies as the spike in transplant activity coincides with peak activity in the national healthcare system.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estações do Ano
/
Obtenção de Tecidos e Órgãos
/
Acidentes de Trânsito
/
Hipóxia Encefálica
/
Transplante de Rim
/
Acidente Vascular Cerebral
/
Infecções
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
BMJ Open
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Reino Unido