The Genetic Background Modulates the Evolution of Fluoroquinolone-Resistance in Mycobacterium tuberculosis.

Castro, Rhastin A D; Ross, Amanda; Kamwela, Lujeko; Reinhard, Miriam; Loiseau, Chloé; Feldmann, Julia; Borrell, Sonia; Trauner, Andrej; Gagneux, Sebastien

Castro, Rhastin A D; Ross, Amanda; Kamwela, Lujeko; Reinhard, Miriam; Loiseau, Chloé; Feldmann, Julia; Borrell, Sonia; Trauner, Andrej; Gagneux, Sebastien.

Afiliação

Castro RAD; Swiss Tropical and Public Health Institute, Basel, Switzerland.
Ross A; University of Basel, Basel, Switzerland.
Kamwela L; Swiss Tropical and Public Health Institute, Basel, Switzerland.
Reinhard M; University of Basel, Basel, Switzerland.
Loiseau C; Swiss Tropical and Public Health Institute, Basel, Switzerland.
Feldmann J; University of Basel, Basel, Switzerland.
Borrell S; Swiss Tropical and Public Health Institute, Basel, Switzerland.
Trauner A; University of Basel, Basel, Switzerland.
Gagneux S; Swiss Tropical and Public Health Institute, Basel, Switzerland.

Mol Biol Evol ; 37(1): 195-207, 2020 Jan 01.

Article em En | MEDLINE | ID: mdl-31532481

Assuntos

Antibacterianos; Evolução Biológica; Farmacorresistência Bacteriana/genética; Patrimônio Genético; Mycobacterium tuberculosis/genética; Ofloxacino; Genoma Bacteriano; Taxa de Mutação

Palavras-chave

Mycobacterium tuberculosis; antimicrobial resistance; epistasis; evolution; fitness; fluoroquinolones; mycobacteria

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ofloxacino / Farmacorresistência Bacteriana / Evolução Biológica / Patrimônio Genético / Antibacterianos / Mycobacterium tuberculosis Idioma: En Revista: Mol Biol Evol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça

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