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Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells.
Maugeri, Marco; Nawaz, Muhammad; Papadimitriou, Alexandros; Angerfors, Annelie; Camponeschi, Alessandro; Na, Manli; Hölttä, Mikko; Skantze, Pia; Johansson, Svante; Sundqvist, Martina; Lindquist, Johnny; Kjellman, Tomas; Mårtensson, Inga-Lill; Jin, Tao; Sunnerhagen, Per; Östman, Sofia; Lindfors, Lennart; Valadi, Hadi.
Afiliação
  • Maugeri M; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 46, Gothenburg, Sweden.
  • Nawaz M; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 46, Gothenburg, Sweden.
  • Papadimitriou A; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 46, Gothenburg, Sweden.
  • Angerfors A; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 431 83, Mölndal, Sweden.
  • Camponeschi A; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 46, Gothenburg, Sweden.
  • Na M; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 46, Gothenburg, Sweden.
  • Hölttä M; Translational Biomarkers and Bioanalysis, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 431 83, Mölndal, Sweden.
  • Skantze P; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 431 83, Mölndal, Sweden.
  • Johansson S; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 431 83, Mölndal, Sweden.
  • Sundqvist M; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 46, Gothenburg, Sweden.
  • Lindquist J; Translational Biomarkers and Bioanalysis, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 431 83, Mölndal, Sweden.
  • Kjellman T; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 431 83, Mölndal, Sweden.
  • Mårtensson IL; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 46, Gothenburg, Sweden.
  • Jin T; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 46, Gothenburg, Sweden.
  • Sunnerhagen P; Department of Chemistry and Molecular Biology, University of Gothenburg, Box 462, 405 30, Gothenburg, Sweden.
  • Östman S; Animal Sciences and Technologies, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 431 83, Mölndal, Sweden.
  • Lindfors L; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 431 83, Mölndal, Sweden.
  • Valadi H; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 46, Gothenburg, Sweden. hadi.valadi@gu.se.
Nat Commun ; 10(1): 4333, 2019 09 24.
Article em En | MEDLINE | ID: mdl-31551417
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Endossomos / RNA Mensageiro / Eritropoetina / Metabolismo dos Lipídeos / Nanopartículas / Vesículas Extracelulares Limite: Animals / Female / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suécia
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Endossomos / RNA Mensageiro / Eritropoetina / Metabolismo dos Lipídeos / Nanopartículas / Vesículas Extracelulares Limite: Animals / Female / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suécia