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Prevalence of human papillomavirus in teenage heterosexual males following the implementation of female and male school-based vaccination in Australia: 2014-2017.
Chow, Eric P F; Tabrizi, Sepehr N; Fairley, Christopher K; Wigan, Rebecca; Machalek, Dorothy A; Regan, David G; Hocking, Jane S; Garland, Suzanne M; Cornall, Alyssa M; Atchison, Steph; Bradshaw, Catriona S; McNulty, Anna; Owen, Louise; Marshall, Lewis; Russell, Darren B; Kaldor, John M; Chen, Marcus Y.
Afiliação
  • Chow EPF; Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia; Central Clinical School, Monash University, Melbourne, Victoria, Australia. Electronic address: eric.chow@monash.edu.
  • Tabrizi SN; Department of Obstetrics Gynaecology, University of Melbourne, Parkville, Victoria, Australia; Murdoch Children's Research Institute, Parkville, Victoria, Australia.
  • Fairley CK; Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia; Central Clinical School, Monash University, Melbourne, Victoria, Australia. Electronic address: CFairley@mshc.org.au.
  • Wigan R; Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia. Electronic address: RWigan@mshc.org.au.
  • Machalek DA; Murdoch Children's Research Institute, Parkville, Victoria, Australia; Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia; Centre for Women's Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia. Electronic address: do
  • Regan DG; The Kirby Institute, UNSW Sydney, Kensington, New South Wales, Australia. Electronic address: Dregan@kirby.unsw.edu.au.
  • Hocking JS; Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia. Electronic address: j.hocking@unimelb.edu.au.
  • Garland SM; Department of Obstetrics Gynaecology, University of Melbourne, Parkville, Victoria, Australia; Murdoch Children's Research Institute, Parkville, Victoria, Australia; Centre for Women's Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia. Electronic address: Suzanne.Garlan
  • Cornall AM; Department of Obstetrics Gynaecology, University of Melbourne, Parkville, Victoria, Australia; Murdoch Children's Research Institute, Parkville, Victoria, Australia; Centre for Women's Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia. Electronic address: alyssa.cornall
  • Atchison S; Murdoch Children's Research Institute, Parkville, Victoria, Australia; Centre for Women's Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia. Electronic address: steph.atchison@mcri.edu.au.
  • Bradshaw CS; Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia; Central Clinical School, Monash University, Melbourne, Victoria, Australia. Electronic address: catriona.bradshaw@monash.edu.
  • McNulty A; Sydney Sexual Health Centre, Sydney Hospital, Sydney, New South Wales, Australia; School of Public Health and Community Medicine, UNSW Sydney, Kensington, New South Wales, Australia. Electronic address: Anna.McNulty@health.nsw.gov.au.
  • Owen L; Statewide Sexual Health Service Tasmania, Tasmania, Australia. Electronic address: louise.owen@ths.tas.gov.au.
  • Marshall L; South Terrace Clinic, Fremantle Hospital, Perth, Western Australia, Australia. Electronic address: Lewis.Marshall@health.wa.gov.au.
  • Russell DB; Cairns Sexual Health Service, Queensland Health, Cairns, North Queensland, Australia; College of Medicine and Dentistry, James Cook University, Cairns, Queensland, Australia. Electronic address: Darren.Russell@health.qld.gov.au.
  • Kaldor JM; The Kirby Institute, UNSW Sydney, Kensington, New South Wales, Australia. Electronic address: jkaldor@kirby.unsw.edu.au.
  • Chen MY; Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia; Central Clinical School, Monash University, Melbourne, Victoria, Australia. Electronic address: mchen@mshc.org.au.
Vaccine ; 37(46): 6907-6914, 2019 10 31.
Article em En | MEDLINE | ID: mdl-31562001
ABSTRACT

BACKGROUND:

Australia introduced a school-based human papillomavirus (HPV) vaccination program for females aged 12-13 years in 2007, with a three-year catch-up to age 26; and for boys aged 12-13 from 2013, with a two-year catch-up to age 15. This study aimed to compare the prevalence of penile HPV between teenage heterosexual males in cohorts eligible or non-eligible for the school-based male vaccination program.

METHODS:

Between 2014 and 2017, sexually active heterosexual males aged 17-19 were recruited from sexual health centres and community sources across Australia. Males provided a self-collected penile swab for 37 HPV genotypes using Roche Linear Array and completed a questionnaire. We calculated adjusted prevalence ratios (aPR) of HPV between males in two periods 2014-2015 (preceding implementation of school-based male vaccination) and 2016-2017 (eligible for school-based male vaccination). Self-reported vaccine doses were confirmed with doses reported to the National HPV Vaccination Program Register.

RESULTS:

Overall, 152 males were recruited in 2014-2015 and 146 in 2016-2017. Numbers of female sex partners and condom use did not differ between the two periods. The prevalence of quadrivalent vaccine-preventable [4vHPV] genotypes (6/11/16/18) was low in both periods (2.6% [2014-15] versus 0.7% [2016-17]; p = 0.371; aPR 0.28 [95% CI 0.03-2.62]). Compared with men in 2014-2015, men in 2016-2017 had a lower prevalence of any of the 37 HPV genotypes tested (21.7% versus 11.6%; aPR 0.62 [95% CI 0.36-1.07]) and any of the 13 high-risk genotypes tested (15.8% versus 7.5%; aPR 0.59 [95% CI 0.30-1.19]). Prevalence of low-risk HPV genotypes did not differ between the two periods. Of the males recruited in 2016-2017, 55% had received ≥1 vaccine dose.

CONCLUSION:

The prevalence of 4vHPV genotypes among teenage heterosexual males in both cohorts was low, presumably due to herd protection from the female-only vaccination program. Further studies are required to determine the impact of universal HPV vaccination on HPV prevalence in males.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Papillomaviridae / Heterossexualidade Tipo de estudo: Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male País/Região como assunto: Oceania Idioma: En Revista: Vaccine Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Papillomaviridae / Heterossexualidade Tipo de estudo: Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male País/Região como assunto: Oceania Idioma: En Revista: Vaccine Ano de publicação: 2019 Tipo de documento: Article