Acid and alkaline solutions of local anesthetics: duration of nerve block and tissue pH.
Anesth Analg
; 64(5): 477-82, 1985 May.
Article
em En
| MEDLINE
| ID: mdl-3158255
ABSTRACT
The effect of solution pH on the duration of rat infraorbital nerve blocks produced by 1% lidocaine or 0.25% bupivacaine at pH 5.0 and 7.4, with and without epinephrine was investigated in a double-blind study. The time course of tissue pH changes subsequent to infections into the infraorbital area or abdominal musculature of rats was measured with a tissue pH microelectrode. Injectable pH had little or no effect upon the duration of block. Tissue pH was minimally changed by the injection of solutions at pH 7.4, but decreased appreciably with injections of solutions at pH 5.0, or if the injectate contained epinephrine.
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Base de dados:
MEDLINE
Assunto principal:
Anestésicos Locais
/
Bloqueio Nervoso
Limite:
Animals
Idioma:
En
Revista:
Anesth Analg
Ano de publicação:
1985
Tipo de documento:
Article