Single photon DNA photocleavage at 830 nm by quinoline dicarbocyanine dyes.

Basnet, Kanchan; Fatemipouya, Tayebeh; St Lorenz, Anna; Nguyen, Mindy; Taratula, Oleh; Henary, Maged; Grant, Kathryn B

Basnet, Kanchan; Fatemipouya, Tayebeh; St Lorenz, Anna; Nguyen, Mindy; Taratula, Oleh; Henary, Maged; Grant, Kathryn B.

Afiliação

Basnet K; Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA. kbgrant@gsu.edu mhenary1@gsu.edu.
Fatemipouya T; Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA. kbgrant@gsu.edu mhenary1@gsu.edu.
St Lorenz A; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, USA.
Nguyen M; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, USA.
Taratula O; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, USA.
Henary M; Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA. kbgrant@gsu.edu mhenary1@gsu.edu and Center for Diagnostics and Therapeutics, Atlanta, GA 30303, USA.
Grant KB; Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA. kbgrant@gsu.edu mhenary1@gsu.edu.

Chem Commun (Camb) ; 55(84): 12667-12670, 2019 Oct 17.

Article em En | MEDLINE | ID: mdl-31584046

ABSTRACT

ABSTRACT

We have synthesized symmetrical carbocyanine dyes in which two 4-quinolinium rings are joined by a pentamethine bridge that is meso-substituted with H or Cl. Irradiation of the halogenated dye at 830 nm produces hydroxyl radicals that generate DNA direct strand breaks. This represents the first reported example of DNA photocleavage upon single photon excitation of a chromophore at wavelengths above 800 nm.

Assuntos

Carbocianinas/química; Clivagem do DNA/efeitos da radiação; DNA/química; Corantes Fluorescentes/química; Quinolinas/química; Antineoplásicos/química; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Sobrevivência Celular/efeitos da radiação; Humanos; Radical Hidroxila/química; Raios Infravermelhos; Estrutura Molecular; Imagem Óptica; Processos Fotoquímicos; Fótons; Espectrometria de Fluorescência

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolinas / DNA / Carbocianinas / Clivagem do DNA / Corantes Fluorescentes Limite: Humans Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article

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