Enteric cholinergic neuropathy in patients with diabetes: Non-invasive assessment with positron emission tomography.
Neurogastroenterol Motil
; 32(1): e13731, 2020 01.
Article
em En
| MEDLINE
| ID: mdl-31595630
ABSTRACT
BACKGROUND:
11 C-Donepezil positron emission tomography (PET) allows non-invasive assessment of cholinergic innervation of visceral organs. We aimed to compare cholinergic innervation in the gut in patients with diabetes mellitus (DM) and in healthy controls (HC).METHODS:
11 C-Donepezil PET and computed tomography (CT) were performed in 19 patients with type 1 DM and gastrointestinal symptoms and in 19 age- and sex-matched HC in a cross-sectional design. KEYRESULTS:
All patients had severe gastrointestinal symptoms when assessed by standard questionnaires. DM patients had significantly increased volume of the small intestinal wall (DM median 557 cm3 [interquartile range [IQR] 446-697] vs HC median 448 cm3 [IQR; 341-518; P < .01]), and the 11 C Donepezil PET uptake was reduced in patients (DM median 7.08 standardized uptake value [SUV] [IQR; 5.94-8.43] vs HC median 9.18 SUV [IQR; 8.57-10.11; P < .01]). A similar pattern was found in colon (DM median volume 1064 cm3 [IQR; 882-1312] vs HC median 939 cm3 [IQR; 785-1081; P = .13] and DM median 1.22 SUV (IQR; 1.08-1.36) vs HC median 1.42 SUV (IQR; 1.32-1.53; P = .03). Furthermore, patients had significantly reduced pancreatic volume (DM median 53 cm3 [IQR; 41-69] vs HC median 98 cm3 [IQR;82-110; P < .01]) and reduced PET uptake of the pancreas (DM median 13.14 SUV [IQR;9.58-15.82] vs HC median 21.46 SUV [IQR;18.97-24.06; P < .01]) as well as the adrenal gland (DM median 7.62 SUV [IQR;7.61;15.82] vs HC median 15.51 SUV [IQR;12.22;19.49; P = .03]). CONCLUSION AND INFERENCES Assessed with 11 C-Donepezil PET/CT, patients with DM and severe bowel symptoms have reduced cholinergic innervation of the gut indicative of parasympathetic denervation.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pseudo-Obstrução Intestinal
/
Diabetes Mellitus Tipo 1
/
Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neurogastroenterol Motil
Assunto da revista:
GASTROENTEROLOGIA
/
NEUROLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Dinamarca