[A new isobenzofuranone derivative from Chaenomeles sinensis and its antibacterial activity].
Zhongguo Zhong Yao Za Zhi
; 44(17): 3745-3748, 2019 Sep.
Article
em Zh
| MEDLINE
| ID: mdl-31602948
ABSTRACT
A new isobenzofuranone derivative was isolated from Chaenomeles sinensis by using various chromatographic techniques,including silica gel,Sephadex LH-20,MCI-gel resin and RP-HPLC. This compound was determined as 2,2-dimethyl-5-( 2-oxopropyl)-2 H-furo[3,4-h]chromen-7( 9 H)-one( 1) by NMR,MS,IR and UV spectra,and was also evaluated for its antibacterial activity. The results showed that it showed prominent antibacterial activity with MIC90 value of( 53. 7±4. 5) mg·L-1 for methicillin resistant Staphylococcus aureus( MRSA) strain. This value is close to that of levofloxacin [with MIC90 value( 50. 2± 4. 2) mg·L-1].
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Benzofuranos
/
Rosaceae
/
Staphylococcus aureus Resistente à Meticilina
/
Antibacterianos
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Assunto da revista:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China