Determination of oxygen r1 at 3 Tesla using samples with a concentration range of dissolved oxygen.
MAGMA
; 33(3): 447-453, 2020 Jun.
Article
em En
| MEDLINE
| ID: mdl-31606810
ABSTRACT
OBJECTIVE:
To investigate the sensitivity of modified Look-Locker inversion recovery (MOLLI) to measure changes in dissolved oxygen (DO) concentrations in water samples and to calculate sequence-specific relaxivity (r1m) and limit of detection (LOD). MATERIALS ANDMETHODS:
Ten water samples with a range of DO concentrations were scanned at 3 T using two variations of MOLLI schemes. Using linear regression the r1 of DO was estimated from the measured DO concentrations and T1 relaxation rates (R1). The results were combined with previously reported values on in vivo stability measures of the MOLLI sequences and used to estimate a LOD.RESULTS:
DO concentrations ranged from 0.5 to 21.6 mg L-1. A linear correlation between DO and R1 was obtained with both MOLLI sequences, with an average correlation coefficient (R2) 0.9 and an average estimated r1 ([Formula see text]) of 4.45 × 10-3 s-1 mg-1 L. Estimated LOD was ≈ 10 mg L-1.CONCLUSION:
MOLLI T1-mapping sequences may be used for detecting dissolved oxygen in vivo at 3 T with an [Formula see text] in the range 4.18-4.8 × 10-3 s-1 mg-1 L and a corresponding LOD for dissolved oxygen of approximately 10 mg L-1. MOLLI-based T1 mapping may be a useful non-invasive tool for quantification of in vivo changes of DO concentration during oxygen challenges.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Processamento de Imagem Assistida por Computador
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Imageamento por Ressonância Magnética
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Interpretação de Imagem Assistida por Computador
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
MAGMA
Assunto da revista:
DIAGNOSTICO POR IMAGEM
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Noruega