Evidence that the multiflorine-derived substituted quinazolidine 55P0251 augments insulin secretion and lowers blood glucose via antagonism at &#945;<sub>2</sub> -adrenoceptors in mice.

Lehner, Zsuzsanna; Stadlbauer, Karin; Brunmair, Barbara; Adorjan, Immanuel; Genov, Miroslav; Kautzky-Willer, Alexandra; Scherer, Thomas; Scheinin, Mika; Bauer, Leonhardt; Fürnsinn, Clemens

Evidence that the multiflorine-derived substituted quinazolidine 55P0251 augments insulin secretion and lowers blood glucose via antagonism at α₂ -adrenoceptors in mice.

Lehner, Zsuzsanna; Stadlbauer, Karin; Brunmair, Barbara; Adorjan, Immanuel; Genov, Miroslav; Kautzky-Willer, Alexandra; Scherer, Thomas; Scheinin, Mika; Bauer, Leonhardt; Fürnsinn, Clemens.

Afiliação

Lehner Z; Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Stadlbauer K; Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Brunmair B; Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Adorjan I; 55pharma Drug Discovery and Development AG, Vienna, Austria.
Genov M; 55pharma Drug Discovery and Development AG, Vienna, Austria.
Kautzky-Willer A; Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Scherer T; Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Scheinin M; Institute of Biomedicine, University of Turku, Turku, Finland.
Bauer L; 55pharma Drug Discovery and Development AG, Vienna, Austria.
Fürnsinn C; Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria.

Diabetes Obes Metab ; 22(3): 290-302, 2020 03.

Article em En | MEDLINE | ID: mdl-31608542

Assuntos

Glicemia; Insulina; Alcaloides; Animais; Insulina/metabolismo; Secreção de Insulina; Masculino; Camundongos; Receptores Adrenérgicos alfa 2/metabolismo

Palavras-chave

animal pharmacology; antidiabetic drug; drug development; drug mechanism; insulin secretion

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicemia / Insulina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Diabetes Obes Metab Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Áustria

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