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Biological sex influences antibody responses to routine vaccinations in the first year of life.
Zimmermann, Petra; Perrett, Kirsten P; Ritz, Nicole; Flanagan, Katie L; Robins-Browne, Roy; van der Klis, Fiona R M; Curtis, Nigel.
Afiliação
  • Zimmermann P; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
  • Perrett KP; Infectious Diseases Research Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
  • Ritz N; Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.
  • Flanagan KL; Department of Paediatrics, Fribourg Hospital HFR and Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
  • Robins-Browne R; Food Allergy Research Group and Melbourne Children's Trial Centre, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
  • van der Klis FRM; Departments of Allergy and Immunology and General Medicine, Royal Children's Hospital, Melbourne, Parkville, Victoria, Australia.
  • Curtis N; School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
Acta Paediatr ; 109(1): 147-157, 2020 01.
Article em En | MEDLINE | ID: mdl-31610635
ABSTRACT

AIM:

We investigated the effect of early-life factors, namely sex, delivery mode, feeding method and antibiotic exposure, on antibody responses to routine vaccinations administered during the first year of life.

METHODS:

One and seven months after the primary course of routine vaccines and 1 month after routine vaccines at 12 months of age, antibodies against 26 vaccine antigens were measured in 398 healthy infants. The geometric mean concentration (GMC) of antibodies (adjusted for effect modifiers with multiple linear regression) and the seroprotection rate for each vaccine were compared for each early-life factor.

RESULTS:

Sex had an influence on GMCs. Antibody concentrations were significantly lower at 7 months of age in females for tetanus and filamentous haemagglutinin and at 13 months of age for pertactin. In contrast, at 13 months of age, antibody concentrations were significantly higher in females for polio type 3, pneumococcal serotype 6A and measles. Sex did not have an influence on seroprotection rates. Delivery mode, feeding method and antibiotic exposure did not exert a substantial influence on vaccine antibody concentrations.

CONCLUSION:

There is a difference between males and females in the humoral response to routine vaccinations in the first year of life.
Assuntos
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caracteres Sexuais / Vacinação / Imunogenicidade da Vacina / Formação de Anticorpos Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Infant / Male Idioma: En Revista: Acta Paediatr Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caracteres Sexuais / Vacinação / Imunogenicidade da Vacina / Formação de Anticorpos Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Infant / Male Idioma: En Revista: Acta Paediatr Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália