Acute Kidney Injury in Non-Intensive Care and Intensive Care Patients Treated with Vancomycin and Piperacillin-Tazobactam.
J Nippon Med Sch
; 87(2): 66-72, 2020 May 15.
Article
em En
| MEDLINE
| ID: mdl-31611508
ABSTRACT
BACKGROUND:
We investigated the incidence of acute kidney injury (AKI) and risk factors associated with vancomycin (VAN) and piperacillin-tazobactam (TZP) combination therapy in non-intensive care unit (ICU) and ICU settings.METHODS:
In this single-center retrospective cohort study, adults who received VAN for ≥48 h during the period from 1 January 2016 through 31 December 2017 were included. The primary endpoint was incidence of AKI.RESULTS:
Data from 593 adults were analyzed. The incidence of AKI was 10.6% overall, 8.0% in the non-TZP group, and 19.8% in the TZP group. In univariate analysis, the odds ratio (OR) for AKI was higher in the TZP group than in the non-TZP group (2.84, 95% CI = 1.64-4.90). In both the non-ICU and ICU settings, the OR for AKI was higher in the TZP group than in the non-TZP group (non-ICU OR = 3.04, 95% CI = 1.52-6.09; ICU OR = 2.51, 95% CI = 1.03-6.08). Furthermore, in propensity score analysis, the OR for AKI was higher in the TZP group than in the non-TZP group (OR = 2.81, 95% CI = 1.52-5.17). In both the non-ICU and ICU settings, the OR for AKI was higher in the TZP group than in the non-TZP group (non-ICU OR = 2.57, 95% CI = 1.17-5.64; ICU OR = 3.51, 95% CI = 1.05-11.6).CONCLUSIONS:
Combined use of TZP in patients receiving VAN increased AKI incidence in non-ICU and ICU settings.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vancomicina
/
Cuidados Críticos
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Injúria Renal Aguda
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Combinação Piperacilina e Tazobactam
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
J Nippon Med Sch
Assunto da revista:
MEDICINA
Ano de publicação:
2020
Tipo de documento:
Article