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Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC.
Wei, Lai; Lee, Derek; Law, Cheuk-Ting; Zhang, Misty Shuo; Shen, Jialing; Chin, Don Wai-Ching; Zhang, Allen; Tsang, Felice Ho-Ching; Wong, Ceci Lok-Sze; Ng, Irene Oi-Lin; Wong, Carmen Chak-Lui; Wong, Chun-Ming.
Afiliação
  • Wei L; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Lee D; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Law CT; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Zhang MS; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Shen J; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Chin DW; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Zhang A; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Tsang FH; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Wong CL; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Ng IO; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Wong CC; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Wong CM; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Nat Commun ; 10(1): 4681, 2019 10 15.
Article em En | MEDLINE | ID: mdl-31615983
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Resistencia a Medicamentos Antineoplásicos / Fosfoglicerato Desidrogenase / Sorafenibe / Neoplasias Hepáticas / Antineoplásicos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Hong Kong
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Resistencia a Medicamentos Antineoplásicos / Fosfoglicerato Desidrogenase / Sorafenibe / Neoplasias Hepáticas / Antineoplásicos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Hong Kong