Growth-coupled changes in glucosaminoglycans (heparan sulfate and hyaluronic acid) in normal and transformed human fibroblasts.
Cell Biol Int Rep
; 9(6): 577-86, 1985 Jun.
Article
em En
| MEDLINE
| ID: mdl-3161629
ABSTRACT
Changes in glycosaminoglycans (GAGs) were investigated in relation to cell density, growth and transformation of human fibroblasts. Relative amounts (percentages of the total GAGs) of heparan sulfate (HS) increased and those of hyaluronic acid (HA) decreased in growth-reduced (serum-starved, exogenous HS-treated and dense) cultures of normal (WI-38) cells. In contrast, transformed (WI-38 CT-1) cells exerted such GAG changes only in serum-starved cultures, but not in HS-treated or dense cultures. These results indicate that the changes in glucosaminoglycans (G1cAGs) (HS and HA) is coupled exclusively with cell growth.
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Base de dados:
MEDLINE
Assunto principal:
Divisão Celular
/
Fibroblastos
/
Glicosaminoglicanos
/
Heparitina Sulfato
/
Ácido Hialurônico
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Biol Int Rep
Ano de publicação:
1985
Tipo de documento:
Article