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Dose-Dependent Inhibition of OATP1B by Rifampicin in Healthy Volunteers: Comprehensive Evaluation of Candidate Biomarkers and OATP1B Probe Drugs.
Mori, Daiki; Kimoto, Emi; Rago, Brian; Kondo, Yusuke; King-Ahmad, Amanda; Ramanathan, Ragu; Wood, Linda S; Johnson, Jillian G; Le, Vu H; Vourvahis, Manoli; David Rodrigues, A; Muto, Chieko; Furihata, Kenichi; Sugiyama, Yuichi; Kusuhara, Hiroyuki.
Afiliação
  • Mori D; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
  • Kimoto E; ADME Sciences, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.
  • Rago B; ADME Sciences, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.
  • Kondo Y; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
  • King-Ahmad A; ADME Sciences, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.
  • Ramanathan R; ADME Sciences, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.
  • Wood LS; Clinical Pharmacogenomics Lab, Early Clinical Development, Pfizer Inc., Groton, Connecticut, USA.
  • Johnson JG; Clinical Pharmacogenomics Lab, Early Clinical Development, Pfizer Inc., Groton, Connecticut, USA.
  • Le VH; Biostatistics, Pfizer Inc., Collegeville, PA, USA.
  • Vourvahis M; Clinical Pharmacology, Pfizer Inc., New York, New York, USA.
  • David Rodrigues A; ADME Sciences, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.
  • Muto C; Pfizer Inc., Tokyo, Japan.
  • Furihata K; P-One Clinic, Keikokai Medical Corp, Tokyo, Japan.
  • Sugiyama Y; RIKEN Innovation Center, Research Cluster for Innovation, RIKEN, Kanagawa, Japan.
  • Kusuhara H; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Clin Pharmacol Ther ; 107(4): 1004-1013, 2020 04.
Article em En | MEDLINE | ID: mdl-31628668
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rifampina / Transportador 1 de Ânion Orgânico Específico do Fígado / Interações Medicamentosas Tipo de estudo: Clinical_trials / Guideline / Risk_factors_studies Limite: Adult / Humans / Male Idioma: En Revista: Clin Pharmacol Ther Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rifampina / Transportador 1 de Ânion Orgânico Específico do Fígado / Interações Medicamentosas Tipo de estudo: Clinical_trials / Guideline / Risk_factors_studies Limite: Adult / Humans / Male Idioma: En Revista: Clin Pharmacol Ther Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão