Rutin protects human periodontal ligament stem cells from TNF-&#945; induced damage to osteogenic differentiation through suppressing mTOR signaling pathway in inflammatory environment.

Zhao, Bin; Zhang, Wenjing; Xiong, Yixuan; Zhang, Yunpeng; Jia, Linglu; Xu, Xin

Rutin protects human periodontal ligament stem cells from TNF-α induced damage to osteogenic differentiation through suppressing mTOR signaling pathway in inflammatory environment.

Zhao, Bin; Zhang, Wenjing; Xiong, Yixuan; Zhang, Yunpeng; Jia, Linglu; Xu, Xin.

Afiliação

Zhao B; School of Stomatology, Shandong University, Jinan, China; Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, China.
Zhang W; School of Stomatology, Shandong University, Jinan, China; Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, China.
Xiong Y; School of Stomatology, Shandong University, Jinan, China; Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, China.
Zhang Y; School of Stomatology, Shandong University, Jinan, China; Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, China; Department of Oral Implantology, the Affiliated Stomatology Hospital of Kunming Medical University, Kunming, China.
Jia L; School of Stomatology, Shandong University, Jinan, China; Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, China.
Xu X; School of Stomatology, Shandong University, Jinan, China; Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, China. Electronic address: xinxu@sdu.edu.cn.

Arch Oral Biol ; 109: 104584, 2020 Jan.

Article em En | MEDLINE | ID: mdl-31630006

Assuntos

Osteogênese; Ligamento Periodontal/citologia; Rutina/farmacologia; Transdução de Sinais; Células-Tronco/efeitos dos fármacos; Serina-Treonina Quinases TOR/metabolismo; Fator de Necrose Tumoral alfa/efeitos adversos; Fosfatase Alcalina/metabolismo; Diferenciação Celular; Células Cultivadas; Humanos; Inflamação; Células-Tronco/citologia

Palavras-chave

Osteogenic differentiation; Periodontal ligament stem cells; Rutin; TNF-α; mTOR

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteogênese / Ligamento Periodontal / Rutina / Células-Tronco / Transdução de Sinais / Fator de Necrose Tumoral alfa / Serina-Treonina Quinases TOR Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Arch Oral Biol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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