Sequencing [4 + 1]-Cycloaddition and Aza-Michael Addition Reactions: A Diastereoselective Cascade for the Rapid Access of Pyrido[2',1':2,3]/Thiazolo[2',3':2,3]imidazo[1,5-<i>a</i>]quinolone Scaffolds as Potential Antibacterial and Anticancer Motifs.

Srinivasulu, Vunnam; Khanfar, Monther; Omar, Hany A; ElAwady, Raafat; Sieburth, Scott McN; Sebastian, Anusha; Zaher, Dana M; Al-Marzooq, Farah; Hersi, Fatema; Al-Tel, Taleb H

Sequencing [4 + 1]-Cycloaddition and Aza-Michael Addition Reactions: A Diastereoselective Cascade for the Rapid Access of Pyrido[2',1':2,3]/Thiazolo[2',3':2,3]imidazo[1,5-a]quinolone Scaffolds as Potential Antibacterial and Anticancer Motifs.

Srinivasulu, Vunnam; Khanfar, Monther; Omar, Hany A; ElAwady, Raafat; Sieburth, Scott McN; Sebastian, Anusha; Zaher, Dana M; Al-Marzooq, Farah; Hersi, Fatema; Al-Tel, Taleb H.

Afiliação

Srinivasulu V; Sharjah Institute for Medical Research , University of Sharjah , P.O. Box 27272, Sharjah , UAE.
Khanfar M; Department of Chemistry , University of Jordan , 11942 Amman , Jordan.
Omar HA; Sharjah Institute for Medical Research , University of Sharjah , P.O. Box 27272, Sharjah , UAE.
ElAwady R; College of Pharmacy , University of Sharjah , P.O. Box 27272, Sharjah , UAE.
Sieburth SM; Sharjah Institute for Medical Research , University of Sharjah , P.O. Box 27272, Sharjah , UAE.
Sebastian A; College of Pharmacy , University of Sharjah , P.O. Box 27272, Sharjah , UAE.
Zaher DM; Temple University , Department of Chemistry , 201 Beury Hall , Philadelphia , Pennsylvania 19122 , United States.
Al-Marzooq F; Sharjah Institute for Medical Research , University of Sharjah , P.O. Box 27272, Sharjah , UAE.
Hersi F; Sharjah Institute for Medical Research , University of Sharjah , P.O. Box 27272, Sharjah , UAE.
Al-Tel TH; Sharjah Institute for Medical Research , University of Sharjah , P.O. Box 27272, Sharjah , UAE.

J Org Chem ; 84(22): 14476-14486, 2019 11 15.

Article em En | MEDLINE | ID: mdl-31633919

Assuntos

Antibacterianos/farmacologia; Antineoplásicos/farmacologia; Compostos Aza/farmacologia; Escherichia coli/efeitos dos fármacos; Quinolonas/farmacologia; Staphylococcus aureus/efeitos dos fármacos; Antibacterianos/síntese química; Antibacterianos/química; Antineoplásicos/síntese química; Antineoplásicos/química; Compostos Aza/química; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Reação de Cicloadição; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Testes de Sensibilidade Microbiana; Estrutura Molecular; Quinolonas/síntese química; Quinolonas/química; Estereoisomerismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Compostos Aza / Quinolonas / Escherichia coli / Antibacterianos / Antineoplásicos Limite: Humans Idioma: En Revista: J Org Chem Ano de publicação: 2019 Tipo de documento: Article

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