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WHO grade, proliferation index, and progesterone receptor expression are different according to the location of meningioma.
Maiuri, Francesco; Mariniello, Giuseppe; Guadagno, Elia; Barbato, Marcello; Corvino, Sergio; Del Basso De Caro, Marialaura.
Afiliação
  • Maiuri F; Department of Neurosciences and Reproductive and Odontostomatological Sciences, Neurosurgical Clinic, "Federico II" University School of Medicine, 5, Via S. Pansini, 80131, Naples, Italy.
  • Mariniello G; Department of Neurosciences and Reproductive and Odontostomatological Sciences, Neurosurgical Clinic, "Federico II" University School of Medicine, 5, Via S. Pansini, 80131, Naples, Italy. giumarin@unina.it.
  • Guadagno E; Department of Advanced Biomedical Sciences, Section of Pathology, University "Federico II" of Naples, Naples, Italy.
  • Barbato M; Department of Neurosciences and Reproductive and Odontostomatological Sciences, Neurosurgical Clinic, "Federico II" University School of Medicine, 5, Via S. Pansini, 80131, Naples, Italy.
  • Corvino S; Department of Neurosciences and Reproductive and Odontostomatological Sciences, Neurosurgical Clinic, "Federico II" University School of Medicine, 5, Via S. Pansini, 80131, Naples, Italy.
  • Del Basso De Caro M; Department of Advanced Biomedical Sciences, Section of Pathology, University "Federico II" of Naples, Naples, Italy.
Acta Neurochir (Wien) ; 161(12): 2553-2561, 2019 12.
Article em En | MEDLINE | ID: mdl-31637512
BACKGROUND: Meningiomas may show a different WHO grade and variable biological and clinical behaviors. The aim of the present study is to assess whether WHO grade, proliferation index, progesterone receptor (PR) expression, histological subtype, neuroradiological features, and the recurrence rate differ depending on the tumor location. METHODS: Three hundred meningiomas operated on from 2006 to 2016 were reviewed. The WHO grade (2007 classification), Ki67-MIB1, progesterone receptor expression, and histological subtype were reexamined and correlated to the meningioma location, classified as medial skull base, lateral skull base, non-skull base, and spinal. RESULTS: Non-skull base and lateral skull base meningiomas showed significantly higher rates of atypical WHO II forms (34% and 25.5% respectively) than medial skull base (12.5%) and spinal ones (7%) (p = 0.0003) and also higher rates of tumors with Ki67-Li > 4% (42% and 38% vs 22% and 14%) (p = 0.0031). The rate of meningiomas with PR expression ≤ 50% was significantly lower in medial skull base (25%) than in non-skull base (48%) (p = 0.009). Meningothelial and transitional meningiomas were more frequent at the skull base (68.5% and 54.5%, respectively), the fibroblastic subtype at the non-skull base (48.5%), and the psammomatous at the spinal canal (50%) (p < 0.00001). Medial skull base and spinal meningiomas showed significantly lower size (p < 0.00001), lower rates of cases with lost arachnoid interface (p = 0.0022), and significantly lower recurrence rates (p = 0.0035) than lateral skull base and non-skull base meningiomas. CONCLUSION: Medial skull base meningiomas show lower size, lower rate of atypical forms, lower Ki67-Li values, and significantly higher PR expression than those at the lateral skull base and non-skull base. This corresponds to lesser aggressiveness and lower recurrence rates.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Progesterona / Neoplasias da Base do Crânio / Proliferação de Células / Neoplasias Meníngeas / Meningioma Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Neurochir (Wien) Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Progesterona / Neoplasias da Base do Crânio / Proliferação de Células / Neoplasias Meníngeas / Meningioma Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Neurochir (Wien) Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Itália