The KDEL receptor has a role in the biogenesis and trafficking of the epithelial sodium channel (ENaC).

Bikard, Yann; Viviano, Jeffrey; Orr, Melissa N; Brown, Lauren; Brecker, Margaret; Jeger, Jonathan Litvak; Grits, Daniel; Suaud, Laurence; Rubenstein, Ronald C

Bikard, Yann; Viviano, Jeffrey; Orr, Melissa N; Brown, Lauren; Brecker, Margaret; Jeger, Jonathan Litvak; Grits, Daniel; Suaud, Laurence; Rubenstein, Ronald C.

Afiliação

Bikard Y; Division of Pulmonary Medicine and Cystic Fibrosis Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104.
Viviano J; Division of Pulmonary Medicine and Cystic Fibrosis Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104.
Orr MN; Division of Pulmonary Medicine and Cystic Fibrosis Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104.
Brown L; Division of Pulmonary Medicine and Cystic Fibrosis Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104.
Brecker M; Division of Pulmonary Medicine and Cystic Fibrosis Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104.
Jeger JL; Division of Pulmonary Medicine and Cystic Fibrosis Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104.
Grits D; Division of Pulmonary Medicine and Cystic Fibrosis Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104.
Suaud L; Division of Pulmonary Medicine and Cystic Fibrosis Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104.
Rubenstein RC; Division of Pulmonary Medicine and Cystic Fibrosis Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104. Electronic address: rrubenst@pennmedicine.upenn

J Biol Chem ; 294(48): 18324-18336, 2019 11 29.

Article em En | MEDLINE | ID: mdl-31653700

Assuntos

Regulador de Condutância Transmembrana em Fibrose Cística/metabolismo; Células Epiteliais/metabolismo; Canais Epiteliais de Sódio/metabolismo; Proteínas de Choque Térmico/metabolismo; Receptores de Peptídeos/metabolismo; Animais; Células Cultivadas; Regulador de Condutância Transmembrana em Fibrose Cística/genética; Cães; Retículo Endoplasmático/metabolismo; Canais Epiteliais de Sódio/genética; Complexo de Golgi/metabolismo; Proteínas de Choque Térmico/genética; Humanos; Células Madin Darby de Rim Canino; Camundongos; Transporte Proteico; Interferência de RNA; Receptores de Peptídeos/genética

Palavras-chave

KDEL receptor; KEEL motif; biogenesis; chaperone; coat complex II (COPII); endoplasmic reticulum (ER); endoplasmic reticulum protein of 29 kDa (ERp29); epithelial sodium channel (ENaC); trafficking

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Peptídeos / Regulador de Condutância Transmembrana em Fibrose Cística / Células Epiteliais / Canais Epiteliais de Sódio / Proteínas de Choque Térmico Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article

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